{"id":"W2338509796","doi":"10.1093/neuonc/nov218.04","title":"IMCT-04TOCA 5: PHASE 2/3 RANDOMIZED, OPEN-LABEL STUDY OF TOCA 511 WITH TOCA FC VERSUS STANDARD OF CARE IN PATIENTS UNDERGOING PLANNED RESECTION FOR RECURRENT HIGH GRADE GLIOMA (NCT02414165)","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Temozolomide; Medicine; Glioma; Phases of clinical research; Clinical endpoint; Anaplastic astrocytoma; Internal medicine; Oncology; Bevacizumab; Lomustine; Cancer research; Astrocytoma; Clinical trial; Chemotherapy; Vincristine; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002227509,0.002478038,0.002205154,0.000702162,0.0005380105,0.001391199,0.001420978,0.002514718,0.0100959],"category_scores_gemma":[0.001478562,0.0007676467,0.00187977,0.0006322683,0.001387909,0.001279042,0.0004073968,0.004394737,0.001669955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001587637,"about_ca_system_score_gemma":0.002496919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001998041,"about_ca_topic_score_gemma":0.006179759,"domain_scores_codex":[0.9994842,0.0002601181,0.00002304056,0.00007963993,0.00004164995,0.0001113295],"domain_scores_gemma":[0.9991857,0.00015511,0.0001955247,0.00004747717,0.00005883984,0.000357292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9443299,0.02377592,0.0008012271,0.0006496139,0.0007236344,0.00007785406,0.00008217635,0.0006156776,0.005914384,0.0002911085,0.003556713,0.0191819],"study_design_scores_gemma":[0.8568861,0.1391722,0.001223603,0.00002481927,0.0002225412,0.00004478491,0.00002850296,0.0005553479,0.0005726641,0.0001619187,0.001090528,0.00001683119],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698019,0.003323998,0.001067761,0.00132915,0.0007163323,0.01401863,0.004421876,0.0004387726,0.004881616],"genre_scores_gemma":[0.9571483,0.002883513,0.003696499,0.003319288,0.0006495823,0.01742082,0.006241339,0.00008934201,0.008551434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0100959,"threshold_uncertainty_score":0.03377414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05435441662414484,"score_gpt":0.3862507224155831,"score_spread":0.3318963057914383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}