{"id":"W2338512737","doi":"10.1038/ncomms11343","title":"Rifampin phosphotransferase is an unusual antibiotic resistance kinase","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Bacteria; Enzyme; Phosphotransferase; Antibiotic resistance; Mutagenesis; Transferase; Kinase; Protein kinase domain; Listeria monocytogenes; Biology; Substrate (aquarium); Microbiology; Chemistry; Binding site; Antibiotics; Biochemistry; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004666238,0.0003495552,0.0002268251,0.0001477732,0.0001755491,0.0003872876,0.0001830499,0.0002821626,0.0006204345],"category_scores_gemma":[0.00007919391,0.0001262371,0.0001738381,0.0001469258,0.0001931653,0.0002136059,0.0001789969,0.0003058795,0.0007134934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138141,"about_ca_system_score_gemma":0.0001973176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002735667,"about_ca_topic_score_gemma":0.0004017391,"domain_scores_codex":[0.9999261,0.000008270326,0.000005741179,0.00002200664,0.00002405505,0.00001377689],"domain_scores_gemma":[0.9999551,0.000004963729,0.00001481506,0.000006288316,0.000004283473,0.0000146256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007833949,0.00001962524,0.001099191,0.00007001062,0.00000836345,0.0004473989,0.00001246688,0.0002792725,0.9845974,0.0007051153,0.0002893288,0.01239353],"study_design_scores_gemma":[0.00002890055,0.0003323229,0.009606129,0.00001017983,0.00002100776,0.006992848,0.0000408985,0.001867046,0.9320571,0.0006632113,0.04835935,0.00002107249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628973,0.008697214,0.01702619,0.0006193252,0.0001414687,0.00004576638,0.0007679419,0.000948425,0.008856453],"genre_scores_gemma":[0.9810875,0.002073687,0.009938508,0.00009496192,0.00004172505,0.0000146133,0.00145759,0.00004275243,0.005248659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006204345,"threshold_uncertainty_score":0.002075553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566790228420544,"score_gpt":0.2953706564734736,"score_spread":0.2797027541892682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}