{"id":"W2338762173","doi":"10.1002/jbm.a.35757","title":"Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP‐9 secretion","year":2016,"lang":"en","type":"article","venue":"Journal of Biomedical Materials Research Part A","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Eidgenössische Technische Hochschule Zürich","keywords":"Macrophage; Materials science; CCL2; Chemokine; Cell biology; Secretion; Giant cell; Foreign-body giant cell; Cell fusion; Stromal cell; Matrix metalloproteinase; Chemotaxis; Surface roughness; Biophysics; Cell; In vitro; Biology; Composite material; Inflammation; Immunology; Pathology; Cancer research; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008304097,0.0003250929,0.0001945523,0.0001952689,0.00006487797,0.000251883,0.0001137578,0.0002931274,0.0008912953],"category_scores_gemma":[0.00014471,0.0002373151,0.0002994356,0.00009429774,0.0001810417,0.0001148452,0.0001774231,0.0002446808,0.0002535346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001122274,"about_ca_system_score_gemma":0.00009149757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002813433,"about_ca_topic_score_gemma":0.0007568903,"domain_scores_codex":[0.9998735,0.000008432904,0.00001081807,0.00002360312,0.00005272964,0.00003092053],"domain_scores_gemma":[0.9998913,0.00002215914,0.00004232473,0.00001507285,0.00001267776,0.00001646803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002196743,0.000006071905,0.000145312,0.0000149159,0.000001438872,0.00002444118,0.000006987187,0.00002190985,0.9993544,0.000006400049,0.000007768856,0.0003883266],"study_design_scores_gemma":[0.0000128726,0.000587457,0.01340857,0.000004977789,0.00001890667,0.0003353477,0.00006218438,0.0006828575,0.9839491,0.00002281733,0.0009069854,0.000007885878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972206,0.0004585499,0.001564064,0.00001851064,0.00001817043,0.00001865659,0.00009499215,0.000042278,0.0005641124],"genre_scores_gemma":[0.9949639,0.0002762155,0.003676044,0.00002709501,0.000006671355,0.00001957254,0.0001292309,0.00001008017,0.0008912369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008912953,"threshold_uncertainty_score":0.002981663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03978566083959754,"score_gpt":0.3065317368207282,"score_spread":0.2667460759811306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}