{"id":"W2338782656","doi":"10.1016/j.stem.2016.03.013","title":"Activation of Endogenous Retroviruses in Dnmt1 −/− ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA","year":2016,"lang":"en","type":"article","venue":"Cell stem cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; DNMT1; Endogenous retrovirus; Methyltransferase; Epigenetics; CpG site; DNA methyltransferase; Gene silencing; DNA; Methylation; Psychological repression; DNA demethylation; Cell biology; Ectopic expression; Genetics; Molecular biology; Gene; Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583254,0.0001367383,0.0001827092,0.00009496663,0.00001838121,0.000004330303,0.0001239861,0.0001624306,0.00001220928],"category_scores_gemma":[0.00003383082,0.000112379,0.0000515162,0.0001745769,0.00002369946,0.00000611536,0.00007540017,0.00004742804,0.000005169949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002763872,"about_ca_system_score_gemma":0.00002892225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004002256,"about_ca_topic_score_gemma":0.00000498108,"domain_scores_codex":[0.9990224,0.00004429893,0.000335826,0.0002856609,0.0001233845,0.0001884555],"domain_scores_gemma":[0.9994054,0.00004474288,0.0001487055,0.0002821324,0.00005410444,0.00006489178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007889517,0.00007292243,0.003580281,0.0001043231,0.000007378549,6.40147e-7,0.0001712395,0.0001968471,0.9939836,4.690316e-7,0.0002322486,0.001571157],"study_design_scores_gemma":[0.0005736005,0.0002009555,0.0005106386,0.00009626948,0.000007932245,5.7774e-7,0.000135719,0.00002493859,0.9974015,0.000002123724,0.0009071569,0.0001385942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954208,0.0005943159,0.003223954,0.00001388725,0.00007307623,0.0002070368,0.00004098388,0.00001094866,0.0004150529],"genre_scores_gemma":[0.9990177,0.0003009018,0.0001885786,0.00001083851,0.00002549862,0.000009890837,0.00008718293,0.00002321704,0.0003361692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003596978,"threshold_uncertainty_score":0.4582681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285154661591605,"score_gpt":0.2536220989671349,"score_spread":0.2407705523512189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}