{"id":"W2338782656","doi":"10.1016/j.stem.2016.03.013","title":"Activation of Endogenous Retroviruses in Dnmt1 −/− ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA","year":2016,"lang":"en","type":"article","venue":"Cell stem cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; DNMT1; Endogenous retrovirus; Methyltransferase; Epigenetics; CpG site; DNA methyltransferase; Gene silencing; DNA; Methylation; Psychological repression; DNA demethylation; Cell biology; Ectopic expression; Genetics; Molecular biology; Gene; Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003155346,0.0004589311,0.0002446752,0.0003651832,0.0003049242,0.0008095203,0.0006628882,0.000538482,0.002375695],"category_scores_gemma":[0.0001730715,0.0003062515,0.000516738,0.0001638908,0.0004772864,0.0004514475,0.0005469061,0.001755545,0.000777069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007406468,"about_ca_system_score_gemma":0.0002378856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006314673,"about_ca_topic_score_gemma":0.001486851,"domain_scores_codex":[0.9994765,0.00007873626,0.00007618553,0.0001122657,0.0001792907,0.0000771149],"domain_scores_gemma":[0.9997656,0.00005276529,0.00006744215,0.0000572764,0.00001428534,0.00004259783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002593464,0.00001175146,0.00009949903,0.00001408488,0.000005631109,0.00003279666,0.00001697861,0.00005607543,0.998681,0.0003738099,0.00002420117,0.0006581598],"study_design_scores_gemma":[0.000003002943,0.00001381969,0.0005309983,0.000002363641,0.000004490257,0.00007647262,0.00001251828,0.0005376118,0.9978145,0.00003507404,0.000966717,0.000002270609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795817,0.0007900869,0.01363975,0.0001646036,0.00009523012,0.00006282633,0.0009786352,0.0003510352,0.004336053],"genre_scores_gemma":[0.9870372,0.000198911,0.005230925,0.00004339715,0.000006290965,0.00003463924,0.0006197221,0.00009005125,0.006738975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375695,"threshold_uncertainty_score":0.007947505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285154661591605,"score_gpt":0.2536220989671349,"score_spread":0.2407705523512189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}