{"id":"W2338792363","doi":"10.1093/neuonc/nov206.16","title":"ATCT-16CODEL (ALLIANCE-N0577; EORTC-26081/2208; NRG-1071; NCIC-CEC-2): PHASE III RANDOMIZED STUDY OF RT VS. RT + TMZ VS. TMZ FOR NEWLY DIAGNOSED 1p/19q-CODELETED ANAPLASTIC GLIOMA. ANALYSIS OF PATIENTS TREATED ON THE ORIGINAL PROTOCOL DESIGN","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; Princess Margaret Cancer Centre; Toronto General Hospital","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Progression-free survival; Gastroenterology; Glioma; Phases of clinical research; Toxicity; Randomized controlled trial; Surgery; Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00154609,0.0008197927,0.00424467,0.001006586,0.0001935693,0.00002875235,0.0005002515,0.000332994,0.0001596881],"category_scores_gemma":[0.002696938,0.0005310985,0.0008982182,0.00232808,0.0003516558,0.0001297666,0.0001052329,0.0003816259,0.00002030077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005613164,"about_ca_system_score_gemma":0.0007421838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004198504,"about_ca_topic_score_gemma":0.0002848808,"domain_scores_codex":[0.9928234,0.001935149,0.002142542,0.001139757,0.0011256,0.0008335493],"domain_scores_gemma":[0.9887788,0.006535667,0.001743578,0.001054821,0.001359466,0.0005277271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8470346,0.06565001,0.04080235,0.0001561305,0.009813792,0.001002026,0.001925715,0.004855012,0.01085948,0.000150516,0.0134469,0.004303478],"study_design_scores_gemma":[0.8533937,0.0748536,0.006827008,0.0001212084,0.0158636,0.00001801415,0.0003258589,0.02516323,0.01796541,0.00005967259,0.004872911,0.000535743],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.881196,0.00002339154,0.0005966419,0.0006349816,0.0002136937,0.1169001,0.0001842313,0.0000943934,0.0001566367],"genre_scores_gemma":[0.8780653,0.00002119146,0.0004355008,0.0005564339,0.0001025028,0.1205165,0.0001860342,0.00009180175,0.00002473529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03397534,"threshold_uncertainty_score":0.9997141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05897382743445861,"score_gpt":0.3590616237671926,"score_spread":0.300087796332734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}