{"id":"W2338837420","doi":"10.1038/srep24726","title":"Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; University of California, San Francisco; Deutsche Forschungsgemeinschaft; National Heart, Lung, and Blood Institute; Gladstone Institutes; Harvard University; Colorado State University; National Science Foundation; Canadian Institutes of Health Research; San Francisco State University; National Institutes of Health","keywords":"Contractility; Sarcomere; Tissue engineering; Myocyte; Biomedical engineering; Cardiac muscle; Inotrope; Chemistry; Cell biology; Biology; Medicine; Anatomy; Cardiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006728515,0.0004279642,0.0003540775,0.0003663286,0.0001520571,0.0003628027,0.0004347967,0.0004139496,0.001700957],"category_scores_gemma":[0.0004971014,0.0002614392,0.0003477945,0.0002101336,0.0002081659,0.000338098,0.000334763,0.0007789354,0.0007515115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00018225,"about_ca_system_score_gemma":0.0002423257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001779763,"about_ca_topic_score_gemma":0.0005054397,"domain_scores_codex":[0.9997362,0.0000440321,0.00003431271,0.00005648029,0.0001106318,0.00001827366],"domain_scores_gemma":[0.999729,0.0001100971,0.00005576504,0.00004531228,0.00003522327,0.00002458887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001444938,0.00001637629,0.0001166624,0.00004975896,0.000006868888,0.00002032135,0.000007792331,0.0003378871,0.9965276,0.0001570013,0.00008015696,0.002665138],"study_design_scores_gemma":[0.00001038658,0.0001650212,0.002579954,0.00001146608,0.00003100145,0.0001315535,0.0000171408,0.004293979,0.9866514,0.0001612735,0.005937778,0.000009044177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4694807,0.006559282,0.5043013,0.0004364619,0.0004078925,0.001521317,0.006498958,0.001611576,0.009182563],"genre_scores_gemma":[0.4980056,0.004026067,0.4857976,0.000351937,0.0001201685,0.001597645,0.005229578,0.0002066699,0.004664659],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001700957,"threshold_uncertainty_score":0.005690277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335885445315336,"score_gpt":0.3135126363612435,"score_spread":0.27992409182971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}