{"id":"W2338837420","doi":"10.1038/srep24726","title":"Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; University of California, San Francisco; Deutsche Forschungsgemeinschaft; National Heart, Lung, and Blood Institute; Gladstone Institutes; Harvard University; Colorado State University; National Science Foundation; Canadian Institutes of Health Research; San Francisco State University; National Institutes of Health","keywords":"Contractility; Sarcomere; Tissue engineering; Myocyte; Biomedical engineering; Cardiac muscle; Inotrope; Chemistry; Cell biology; Biology; Medicine; Anatomy; Cardiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001830371,0.0002179107,0.0005416309,0.000196755,0.0002091222,0.00003760599,0.00007934073,0.00008349671,0.0000771956],"category_scores_gemma":[0.001820682,0.0001094873,0.0002905848,0.0002953955,0.000364211,0.00005713786,0.00003823034,0.00009060033,0.00001993849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006286109,"about_ca_system_score_gemma":0.0001813212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003594286,"about_ca_topic_score_gemma":6.386343e-7,"domain_scores_codex":[0.9977754,0.0001200075,0.000502937,0.000790637,0.0004317841,0.0003791773],"domain_scores_gemma":[0.9980502,0.0003691207,0.0002089818,0.0008176269,0.0003124251,0.0002416712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000413921,0.00007620697,0.0001672679,0.00004583515,0.00005808208,0.0002328945,0.0002692751,0.000008760775,0.9586542,0.000005663066,0.03846433,0.001603573],"study_design_scores_gemma":[0.001172396,0.0002537345,0.01058354,0.0002522811,0.0001622033,0.00007428275,0.0001592471,0.00002654576,0.8025249,0.0001691151,0.1843994,0.0002223194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875739,0.002643123,0.001050676,0.00204188,0.005780983,0.0006558212,0.00001205166,0.000166979,0.00007455731],"genre_scores_gemma":[0.9054745,0.00002993976,0.006231626,0.00002291433,0.0003951136,0.00008128413,0.00004801979,0.00002685804,0.08768971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1561293,"threshold_uncertainty_score":0.4464762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335885445315336,"score_gpt":0.3135126363612435,"score_spread":0.27992409182971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}