{"id":"W2339030503","doi":"10.3389/fncel.2016.00089","title":"Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders","year":2016,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Mental Health; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Reelin; Dendritic spine; Neuroscience; Synaptic plasticity; Epigenetics; Postsynaptic potential; GABAergic; Schizophrenia (object-oriented programming); Neuroplasticity; Reeler; Psychology; Biology; Cell biology; Receptor; Hippocampal formation; Psychiatry; Extracellular matrix; Inhibitory postsynaptic potential; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007020283,0.0007689897,0.001334314,0.003018453,0.00030357,0.0001533175,0.001701728,0.0003677005,0.00005572741],"category_scores_gemma":[0.001327821,0.0006346741,0.0002416115,0.005771144,0.001651341,0.0004392329,0.0005867743,0.001557655,0.0001601612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000134797,"about_ca_system_score_gemma":0.0003616024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005647314,"about_ca_topic_score_gemma":0.000003746359,"domain_scores_codex":[0.9918404,0.001883611,0.001090317,0.003024699,0.0007765347,0.001384457],"domain_scores_gemma":[0.9979377,0.0004199366,0.0004504588,0.0008328101,0.00001224462,0.0003467957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006432827,0.0002933771,0.000535758,0.001227948,0.000001993253,0.001382642,0.00003115707,0.00001235788,0.03057853,0.0001803352,0.0007365805,0.964955],"study_design_scores_gemma":[0.002099849,0.000506204,0.000378793,0.002116668,0.00007328003,0.0003486767,0.000006704958,0.001217881,0.001263308,0.001173105,0.9894145,0.001401017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003113243,0.9815235,0.0002871015,0.0002030682,0.01013974,0.002412102,0.00002324348,0.0001871043,0.002110929],"genre_scores_gemma":[0.003377068,0.9913256,0.00004278102,0.0002160761,0.00005725131,0.0001370413,6.553929e-7,0.0001854872,0.004658108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9886779,"threshold_uncertainty_score":0.9996105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0304744353280422,"score_gpt":0.3076424724427445,"score_spread":0.2771680371147023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}