{"id":"W2339175766","doi":"10.1101/gr.197897.115","title":"Impact of the X Chromosome and sex on regulatory variation","year":2016,"lang":"en","type":"article","venue":"Genome Research","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Air Force Office of Scientific Research; National Human Genome Research Institute; National Institute of Mental Health; National Defense Science and Engineering Graduate; National Institutes of Health; Edward Mallinckrodt, Jr. Foundation","keywords":"Biology; Autosome; Genetics; Expression quantitative trait loci; Quantitative trait locus; Genetic variation; X chromosome; Chromosome; Gene; Genome; Evolutionary biology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004781113,0.0001870228,0.000272355,0.0003834612,0.0001556093,0.0005472549,0.0001756447,0.0001515104,0.0017713],"category_scores_gemma":[0.0007134135,0.00007896142,0.0001834577,0.0003703176,0.0004902713,0.0002305098,0.000311865,0.0002149812,0.0001716115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226363,"about_ca_system_score_gemma":0.000184124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000569299,"about_ca_topic_score_gemma":0.0005274757,"domain_scores_codex":[0.9995277,0.0001325289,0.00002680041,0.000167218,0.0001087849,0.00003703518],"domain_scores_gemma":[0.9995664,0.000216882,0.00009955904,0.00005149007,0.00003465065,0.00003095419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007567647,0.0000485035,0.2707079,0.0002879016,0.0003820642,0.001183355,0.0005801558,0.0006487069,0.6427914,0.006713781,0.0003669827,0.07553253],"study_design_scores_gemma":[0.00002079416,0.0001726006,0.9233872,0.00004318378,0.0001680131,0.001981832,0.0001944955,0.001219201,0.06197885,0.004037586,0.006776968,0.00001923314],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796608,0.007823301,0.006396994,0.0003096182,0.00003142311,0.00001051794,0.0006180033,0.00005227902,0.005097118],"genre_scores_gemma":[0.9965753,0.001471982,0.0008119533,0.000117808,0.00001945398,0.000007656613,0.0002033188,0.00002015626,0.0007723574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0017713,"threshold_uncertainty_score":0.005925596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03138082688305092,"score_gpt":0.3396256866333344,"score_spread":0.3082448597502834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}