{"id":"W2339209391","doi":"10.1086/685821","title":"Clinical Implications of Riociguat Pharmacokinetics and Pharmacodynamics: Introduction to the Riociguat Clinical Pharmacology Supplement","year":2016,"lang":"en","type":"article","venue":"Pulmonary Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Riociguat; Medicine; Pharmacodynamics; Pharmacokinetics; Pharmacology; Clinical pharmacology; Guanylate cyclase; Receptor; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041697,0.0001804313,0.0003741411,0.000249359,0.0001475335,0.000008728263,0.0001384839,0.0001038955,0.0003824949],"category_scores_gemma":[0.0001918875,0.0001080543,0.0001705461,0.0004759118,0.0002520127,0.0001234989,0.0001307119,0.0002143406,0.00007754957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009540312,"about_ca_system_score_gemma":0.0001113939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001559502,"about_ca_topic_score_gemma":0.00000298498,"domain_scores_codex":[0.9975483,0.0003692233,0.0008621198,0.0005518686,0.0003406246,0.0003278607],"domain_scores_gemma":[0.9982441,0.0004443013,0.0001956712,0.0004081206,0.0003342058,0.0003735821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007524767,0.001287172,0.5412623,0.00003472848,0.000351459,0.00005403749,0.0000172026,0.00002425275,0.0993192,0.0001509275,0.02052152,0.3362247],"study_design_scores_gemma":[0.002536409,0.0003946326,0.9182947,0.00002461795,0.0004122381,0.0002524784,0.0000164376,0.002773087,0.001110464,0.0003903562,0.0736683,0.0001262237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8285373,0.0003846452,0.001770796,0.1666601,0.0009037473,0.001428626,0.0001073689,0.00004444991,0.0001629313],"genre_scores_gemma":[0.9926999,0.002466124,0.0006178336,0.001483472,0.002138637,0.000112803,0.0001336365,0.00002520484,0.0003224373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3770325,"threshold_uncertainty_score":0.4406328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05488663135074486,"score_gpt":0.4169312931803156,"score_spread":0.3620446618295707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}