{"id":"W2339221030","doi":"10.1200/jco.2009.27.15_suppl.e14525","title":"Phase I study of daily administration of MGCD265 to patients with advanced malignancies (Study 265–101)","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Neutropenia; Pharmacokinetics; Toxicity; Pharmacodynamics; Internal medicine; Gastroenterology; Tyrosine-kinase inhibitor; Pharmacology; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001139113,0.00139876,0.001218475,0.0003815021,0.0003270177,0.0008953396,0.0007709831,0.0009430386,0.00312954],"category_scores_gemma":[0.0006287972,0.0004995281,0.0007535208,0.0003395725,0.0008416012,0.0004850518,0.0003112553,0.002481384,0.0008898887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008140714,"about_ca_system_score_gemma":0.001522719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009638434,"about_ca_topic_score_gemma":0.002144716,"domain_scores_codex":[0.9997039,0.0001377603,0.00001419273,0.00005185643,0.00003097593,0.00006128728],"domain_scores_gemma":[0.9994006,0.00009468533,0.0001126988,0.00005587265,0.00003843746,0.0002976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5579602,0.1394391,0.01466903,0.001106704,0.001309401,0.000730058,0.0006694273,0.009500631,0.1476768,0.0009333649,0.01122084,0.1147845],"study_design_scores_gemma":[0.3416624,0.6282409,0.01644236,0.00003886576,0.0002157508,0.0004283807,0.00007030449,0.001896086,0.006921548,0.000175635,0.003872863,0.00003489112],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946332,0.0006192947,0.0005422715,0.0002168843,0.00006022574,0.001561692,0.0007578284,0.00009737416,0.001511115],"genre_scores_gemma":[0.9918407,0.0007482287,0.001256983,0.0004501895,0.0001057704,0.001135506,0.00244247,0.00002262155,0.001997398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00312954,"threshold_uncertainty_score":0.01046938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09897926098553333,"score_gpt":0.5188007457300592,"score_spread":0.4198214847445259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}