{"id":"W2339257508","doi":"10.1021/acs.molpharmaceut.5b00611","title":"Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-<i>co</i>-glycolide) Polymeric Matrix Composition","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Curcumin; PLGA; Neuroprotection; Chemistry; Bioavailability; Antioxidant; Pharmacology; Biochemistry; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001068927,0.0003755242,0.000337147,0.0001729974,0.0001173568,0.0001578061,0.0001801884,0.0002847073,0.0006808349],"category_scores_gemma":[0.00007450385,0.0001093897,0.0003087272,0.0001220378,0.0001405791,0.0002448,0.0001091796,0.000318818,0.0002786642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590521,"about_ca_system_score_gemma":0.0002569636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004437381,"about_ca_topic_score_gemma":0.004922069,"domain_scores_codex":[0.9999349,0.000006927002,0.000008024559,0.00001603509,0.00001383491,0.00002035831],"domain_scores_gemma":[0.9999537,0.00001001663,0.000008524095,0.000005481642,0.00001359585,0.000008530764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009619658,0.00002844338,0.00005591274,0.00004964476,0.00000597315,0.00005933648,0.00001978706,0.00005524411,0.9988794,0.00002028649,0.00003152503,0.000698329],"study_design_scores_gemma":[0.000006380217,0.0001937335,0.001137131,0.000004760113,0.00001924077,0.00005918831,0.00002112446,0.0004639242,0.997741,0.0000104264,0.0003393604,0.000003702855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945281,0.002083622,0.001593346,0.00009836408,0.00003344739,0.00001837398,0.0003369412,0.0000926189,0.001215146],"genre_scores_gemma":[0.9929652,0.001466958,0.002013763,0.00004076325,0.000007320502,0.00005206355,0.0004296004,0.00002502486,0.002999213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004437381,"threshold_uncertainty_score":0.008823097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434826086989135,"score_gpt":0.2959012556025214,"score_spread":0.2715529947326301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}