{"id":"W2339257508","doi":"10.1021/acs.molpharmaceut.5b00611","title":"Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-<i>co</i>-glycolide) Polymeric Matrix Composition","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Curcumin; PLGA; Neuroprotection; Chemistry; Bioavailability; Antioxidant; Pharmacology; Biochemistry; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459199,0.0002360773,0.0002429178,0.00008709999,0.00005541847,0.00001717017,0.0002168953,0.0001249354,0.000005314814],"category_scores_gemma":[0.00004896681,0.0002291204,0.00009154734,0.0002267122,0.0003350035,0.000008251965,0.0001463532,0.0001768464,0.000007369075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001833372,"about_ca_system_score_gemma":0.000117128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002672654,"about_ca_topic_score_gemma":4.357654e-7,"domain_scores_codex":[0.9984349,0.0001408486,0.0004035824,0.0003901945,0.0003580344,0.000272456],"domain_scores_gemma":[0.9989877,0.00001455949,0.0002347179,0.000346557,0.0001716151,0.0002449028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003958225,0.0004008504,0.0001100509,0.00006956969,0.00004834365,0.000004521415,0.0001296349,0.00009207652,0.995573,0.00006424842,0.00006204536,0.003049825],"study_design_scores_gemma":[0.001119921,0.0005984135,0.0002011099,0.00002050649,0.00008845828,0.00002482113,0.0001222499,0.0006151652,0.9912521,0.00005922015,0.0056914,0.0002066847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928049,0.004778851,0.001227982,0.0003098217,0.0000591619,0.000501616,0.00007185475,0.00002173569,0.0002240792],"genre_scores_gemma":[0.9988484,0.00006696248,0.0004659934,0.0003592571,0.00006970762,0.00004811905,0.00004937023,0.00004323639,0.00004899069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006043465,"threshold_uncertainty_score":0.934326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434826086989135,"score_gpt":0.2959012556025214,"score_spread":0.2715529947326301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}