{"id":"W2339497078","doi":"10.1158/1078-0432.ccr-15-2507","title":"Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Cancer Research UK","keywords":"Carcinoembryonic antigen; Medicine; Immunology; Vaccination; DNA vaccination; Adverse effect; Antigen; DNA; Virology; Cancer; Immunization; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007293594,0.0002697218,0.0003723573,0.0001141936,0.00007905477,0.0001998752,0.00009527563,0.000297559,0.001315734],"category_scores_gemma":[0.001091266,0.0000692223,0.0002111162,0.00007864385,0.0001847657,0.0001888646,0.0001600437,0.0004032177,0.0001513034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759667,"about_ca_system_score_gemma":0.0001374135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007471452,"about_ca_topic_score_gemma":0.0001213392,"domain_scores_codex":[0.9996634,0.0001534924,0.00002258664,0.00003204526,0.00005833113,0.00007014859],"domain_scores_gemma":[0.9986501,0.00040031,0.0005517597,0.00005581995,0.000111614,0.0002303125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05892492,0.007751767,0.5798323,0.001010362,0.0009560888,0.0009386959,0.0001906455,0.001779479,0.217108,0.0001516116,0.0006623454,0.130694],"study_design_scores_gemma":[0.001326345,0.1238192,0.8309519,0.00006938611,0.0005626569,0.001566629,0.00008762841,0.002121756,0.03768695,0.0001124222,0.00167578,0.00001940188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985713,0.0007741331,0.0001704628,0.00003293164,0.000007255401,0.00003514758,0.00003165332,0.000003401154,0.0003736259],"genre_scores_gemma":[0.9995835,0.00008562799,0.00005609192,0.00003016565,0.00001190785,0.00001350956,0.00005312094,7.767187e-7,0.0001651746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315734,"threshold_uncertainty_score":0.004401624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09134343134888132,"score_gpt":0.4340743761850276,"score_spread":0.3427309448361463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}