{"id":"W2339555840","doi":"10.1021/acs.jnatprod.5b01082","title":"IR and Vibrational Circular Dichroism Spectroscopy of Matrine- and Artemisinin-Type Herbal Products: Stereochemical Characterization and Solvent Effects","year":2016,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Molecular spectroscopy and chirality","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; Canada Foundation for Innovation; University of Alberta","keywords":"Matrine; Artemisinin; Dihydroartemisinin; Chemistry; Circular dichroism; Oxymatrine; Vibrational circular dichroism; Solvent; Sophora flavescens; Stereochemistry; Combinatorial chemistry; Organic chemistry; Chromatography; Medicine; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875092,0.0002724036,0.0001688,0.0002223089,0.0002039846,0.0001471368,0.0001959794,0.0002571317,0.0009382148],"category_scores_gemma":[0.0003058125,0.0001043388,0.0001826969,0.0003123156,0.0002577229,0.0003282777,0.000142846,0.0003908204,0.0001148342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001121565,"about_ca_system_score_gemma":0.0001102742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004041483,"about_ca_topic_score_gemma":0.0005286661,"domain_scores_codex":[0.9998927,0.00002284079,0.000004525666,0.00002391047,0.00004102189,0.00001501394],"domain_scores_gemma":[0.9998797,0.00004301708,0.00003393682,0.00001013231,0.00002122812,0.0000119406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002596807,0.00003475235,0.0009369511,0.0002068068,0.00001526125,0.00008115199,0.00009499517,0.0005153209,0.9901535,0.0004345948,0.0001350819,0.007131991],"study_design_scores_gemma":[0.0000169645,0.0002988431,0.006262282,0.00001064112,0.00002040705,0.0001944045,0.0001044311,0.00530652,0.9859219,0.0001343014,0.001706693,0.00002260057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878761,0.002851306,0.005850028,0.0001145179,0.00004874235,0.00002629021,0.000301135,0.00005403447,0.002877741],"genre_scores_gemma":[0.9941053,0.001059841,0.003878131,0.00007101738,0.00001246902,0.00001776406,0.0001795285,0.000009448921,0.0006665233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009382148,"threshold_uncertainty_score":0.003138602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005552871278465873,"score_gpt":0.2286920930701863,"score_spread":0.2231392217917205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}