{"id":"W2339678743","doi":"10.1002/em.22010","title":"Genetic and epigenetic variation in the <i>DNMT3B</i> and <i>MTHFR</i> genes and colorectal adenoma risk","year":2016,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Kingston General Hospital; University of Alberta; Université de Montréal","funders":"","keywords":"DNA methylation; DNMT3B; Methylation; Methylenetetrahydrofolate reductase; CpG site; Genotype; Epigenetics; Biology; Genetics; Odds ratio; Methyltransferase; Colorectal adenoma; Colorectal cancer; Internal medicine; Molecular biology; Gene; Medicine; Cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006002248,0.0002024535,0.0002678735,0.0005030737,0.0001589836,0.0002476464,0.0001708205,0.0003336374,0.001276951],"category_scores_gemma":[0.001648667,0.000261133,0.0004347996,0.0005348384,0.0002023122,0.0001310001,0.0002004547,0.0003689494,0.0001455854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462426,"about_ca_system_score_gemma":0.0001324869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004261805,"about_ca_topic_score_gemma":0.004051507,"domain_scores_codex":[0.999668,0.0001209164,0.00002635536,0.0001029312,0.00005366868,0.00002822017],"domain_scores_gemma":[0.9989551,0.0002898273,0.000443477,0.00008921594,0.00008970891,0.0001326175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006506444,0.00003324615,0.9909862,0.00002327192,0.0002932313,0.00006253654,0.00005946106,0.00009436902,0.005216416,0.00003283585,0.00003422274,0.002513549],"study_design_scores_gemma":[0.000007581298,0.0001260298,0.9989318,0.000003460804,0.00007514754,0.0002178364,0.00001901912,0.0001913327,0.0003200696,0.00002305587,0.00008238353,0.00000210168],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988166,0.0004385466,0.0002780678,0.00002473435,0.000002411751,0.000006753797,0.0002026073,0.000005391138,0.0002248956],"genre_scores_gemma":[0.9992482,0.0001280744,0.0003200306,0.00001057181,0.000004436824,0.000004427786,0.0001294801,0.000001821022,0.0001529112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004261805,"threshold_uncertainty_score":0.008473992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002724323606094513,"score_gpt":0.1773809875592247,"score_spread":0.1746566639531302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}