{"id":"W2339791053","doi":"10.1016/j.bpj.2015.11.634","title":"Insertion of Crosslinkable Amino Acids into the IKS Channel Complex Demonstrates a Variable KCNQ1:KCNE1 Stoichiometry of up to 4:4","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Potassium channel; Amino acid; Transmembrane domain; Protein subunit; Stoichiometry; Conductance; Biophysics; Stereochemistry; Biochemistry; Biology; Gene; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004703727,0.0006227998,0.000262476,0.0001843782,0.0003085619,0.0004640239,0.0005079868,0.0006457318,0.003545889],"category_scores_gemma":[0.0005316705,0.0002156613,0.0002866075,0.0001747587,0.0005615237,0.0005593806,0.0003632289,0.001067026,0.0009604699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006705198,"about_ca_system_score_gemma":0.0003029223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006361145,"about_ca_topic_score_gemma":0.0008493391,"domain_scores_codex":[0.9996669,0.00004781209,0.00004282187,0.0001144409,0.00007316913,0.00005487258],"domain_scores_gemma":[0.999168,0.0002813047,0.0002186898,0.0001286834,0.00005605246,0.0001471961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008454946,0.00002120632,0.00009302526,0.00001750926,0.00000567913,0.00002588101,0.00001417682,0.00005136598,0.9992307,0.00008316294,0.00001538637,0.0003572807],"study_design_scores_gemma":[0.00001287327,0.00006272611,0.0006087787,0.000003463475,0.00001131239,0.00008475689,0.00001220292,0.0004285008,0.9978949,0.0000342836,0.0008404474,0.000005851299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923029,0.0002832226,0.005684309,0.0001476482,0.00006952499,0.00002646056,0.0001102123,0.0001252585,0.001250519],"genre_scores_gemma":[0.9922138,0.0002097669,0.004911329,0.0001122521,0.0000138932,0.00002748695,0.0003752166,0.0001550658,0.001981152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003545889,"threshold_uncertainty_score":0.01186216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773780917877291,"score_gpt":0.2783020936365692,"score_spread":0.2605642844577963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}