{"id":"W2339791333","doi":"10.1002/ana.24664","title":"α‐synuclein genetic variability: A biomarker for dementia in Parkinson disease","year":2016,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging; Avid Radiopharmaceuticals; Genentech; National Institutes of Health; NIHR Oxford Biomedical Research Centre; Canada Excellence Research Chairs, Government of Canada; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Eli Lilly and Company; Alzheimer Society; Michael J. Fox Foundation for Parkinson's Research; Little Family Foundation; Medical Research Council; International Parkinson and Movement Disorder Society; Biogen; GlaxoSmithKline; Parkinson's UK; Pfizer; Elan; Genome British Columbia","keywords":"Dementia; Parkinsonism; Parkinson's disease; Dementia with Lewy bodies; Locus (genetics); Haplotype; Disease; Single-nucleotide polymorphism; Genetics; Medicine; Genetic association; Bioinformatics; Oncology; Biology; Genotype; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007740105,0.0003746804,0.0003802876,0.001004073,0.0003335982,0.0006463342,0.0003080551,0.0004517955,0.0008151185],"category_scores_gemma":[0.001324287,0.0001273844,0.0002113658,0.00108489,0.0003491416,0.0002564325,0.0004817517,0.0004115599,0.0001594732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962163,"about_ca_system_score_gemma":0.0001935742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006405867,"about_ca_topic_score_gemma":0.0009624523,"domain_scores_codex":[0.999706,0.00007158011,0.00003868692,0.00009385188,0.00006764843,0.00002212668],"domain_scores_gemma":[0.9992356,0.0001305407,0.0004184931,0.00003910824,0.00007906842,0.00009716042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002613246,0.00003458614,0.9849689,0.0000432253,0.00009853313,0.0002128151,0.00005631569,0.0001921019,0.00740151,0.00004305427,0.0001365334,0.006550999],"study_design_scores_gemma":[0.00001023665,0.0001606454,0.996075,0.00002962519,0.00006618831,0.001033784,0.00006858946,0.0006521239,0.001264802,0.00022177,0.0004115385,0.000005642421],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962286,0.002174295,0.0006316282,0.0001102829,0.00001086263,0.00001323227,0.0003455897,0.0000199103,0.0004656342],"genre_scores_gemma":[0.9984653,0.0003106977,0.0007929975,0.00004179485,0.000017167,0.00000757715,0.0002422175,0.000002500586,0.0001199109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004073,"threshold_uncertainty_score":0.004093409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05544506173393928,"score_gpt":0.3185079108956448,"score_spread":0.2630628491617055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}