{"id":"W2339791333","doi":"10.1002/ana.24664","title":"α‐synuclein genetic variability: A biomarker for dementia in Parkinson disease","year":2016,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging; Avid Radiopharmaceuticals; Genentech; National Institutes of Health; NIHR Oxford Biomedical Research Centre; Canada Excellence Research Chairs, Government of Canada; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Eli Lilly and Company; Alzheimer Society; Michael J. Fox Foundation for Parkinson's Research; Little Family Foundation; Medical Research Council; International Parkinson and Movement Disorder Society; Biogen; GlaxoSmithKline; Parkinson's UK; Pfizer; Elan; Genome British Columbia","keywords":"Dementia; Parkinsonism; Parkinson's disease; Dementia with Lewy bodies; Locus (genetics); Haplotype; Disease; Single-nucleotide polymorphism; Genetics; Medicine; Genetic association; Bioinformatics; Oncology; Biology; Genotype; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930582,0.0001355832,0.0002848933,0.0001418426,0.00002039833,0.00000267182,0.00007740191,0.00007249537,0.000142147],"category_scores_gemma":[0.000248166,0.00009570135,0.0001417753,0.00009360658,0.0000700573,0.00003674085,0.00003925002,0.0000331777,0.00001578695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005605646,"about_ca_system_score_gemma":0.00007044571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001453912,"about_ca_topic_score_gemma":0.00000777,"domain_scores_codex":[0.9987852,0.0001146071,0.0002779625,0.0003900485,0.0001120104,0.0003201681],"domain_scores_gemma":[0.9991124,0.0001768094,0.00008683322,0.0003390375,0.00007323689,0.0002117306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006094801,0.001429486,0.9256304,0.0001306152,0.0002768804,0.0003912826,0.00001614086,0.00000140296,0.01320834,0.0007290448,0.001249743,0.05084188],"study_design_scores_gemma":[0.002530375,0.0007712868,0.9249932,0.00002749165,0.0001454281,0.000007778082,5.107353e-7,0.0001651504,0.00152675,0.01000426,0.05974823,0.00007957425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868132,0.0004503145,0.0006558945,0.01120178,0.000104291,0.0005421082,0.00009824664,0.00002110995,0.0001130745],"genre_scores_gemma":[0.9966124,0.0002304349,0.0003149625,0.0026136,0.00003049147,0.0001262274,0.000008864566,0.00002163462,0.00004138554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05849849,"threshold_uncertainty_score":0.3902588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05544506173393928,"score_gpt":0.3185079108956448,"score_spread":0.2630628491617055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}