{"id":"W2339885882","doi":"10.1158/1557-3265.ovcasymp14-poster-biol-1327","title":"Abstract POSTER-BIOL-1327: Small cell carcinoma of the ovary, hypercalcemic type displays frequent inactivating germline and somatic mutations in SMARCA4","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University Health Network; University of British Columbia; BC Cancer Agency","funders":"","keywords":"SMARCA4; Biology; Germline; Exome sequencing; Germline mutation; Cancer research; Ovarian cancer; Small-cell carcinoma; Somatic cell; Mutation; Cancer; Carcinoma; Genetics; Chromatin remodeling; Epigenetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001344475,0.0001108525,0.0002033094,0.00004797653,0.00006898095,0.00001908309,0.0002743524,0.0001686518,0.00002234386],"category_scores_gemma":[0.0006832401,0.00008207288,0.00007259104,0.0002008418,0.0002801574,0.000004915862,0.0002671434,0.0004458415,0.000003752993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007687844,"about_ca_system_score_gemma":0.000688333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276807,"about_ca_topic_score_gemma":0.0005306834,"domain_scores_codex":[0.9983644,0.000246458,0.0005074727,0.0003384257,0.0002583641,0.0002849044],"domain_scores_gemma":[0.9988688,0.0002095521,0.0001127329,0.0003935501,0.0002804749,0.0001349244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005805299,0.0004482043,0.4517053,0.0004053878,0.00003658436,0.000009065184,0.0005039166,0.0006019658,0.5315054,0.00002231932,0.001110476,0.01307089],"study_design_scores_gemma":[0.005304141,0.001463045,0.7482311,0.0005434764,0.00004754143,0.00001892903,0.001469008,0.00390804,0.2359132,0.001108293,0.0014499,0.0005433228],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959483,0.0019883,0.00001485789,0.000386202,0.0001723548,0.0002741977,0.00002362409,0.000003740855,0.001188465],"genre_scores_gemma":[0.9990418,0.0002424335,0.0001853407,0.00008206654,0.0002005156,0.00003249759,0.00002379574,0.00002007751,0.0001714708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2965258,"threshold_uncertainty_score":0.3346835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1920293467510057,"score_gpt":0.441347908459064,"score_spread":0.2493185617080584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}