{"id":"W2340373989","doi":"10.1534/genetics.115.183889","title":"Functional Divergence of the Nuclear Receptor<i>NR2C1</i>as a Modulator of Pluripotentiality During Hominid Evolution","year":2016,"lang":"en","type":"article","venue":"Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Division of Graduate Education; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Tula Foundation; George Washington University; James S. McDonnell Foundation; National Institutes of Health; National Science Foundation","keywords":"Biology; Natural selection; Gene; Induced pluripotent stem cell; Evolutionary biology; Gene regulatory network; Phenotype; Genetics; Functional divergence; Cellular differentiation; Genetic Fitness; Computational biology; Embryonic stem cell; Gene expression; Selection (genetic algorithm); Gene family","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001234993,0.0002665241,0.0002676943,0.0003295647,0.0002743793,0.0004032531,0.0003165987,0.000332054,0.0006140779],"category_scores_gemma":[0.001211628,0.0001792926,0.0001983668,0.0003161293,0.0006553021,0.0002434192,0.0003154167,0.0004021765,0.00009874822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388909,"about_ca_system_score_gemma":0.0002120058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001362163,"about_ca_topic_score_gemma":0.001622013,"domain_scores_codex":[0.9995472,0.0001485372,0.00003642213,0.0001267086,0.0001012113,0.00003989628],"domain_scores_gemma":[0.9992747,0.0003126066,0.0001356843,0.0001205547,0.0001082169,0.00004831401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002438874,0.0000152884,0.02348638,0.00004369329,0.00002510358,0.00007459633,0.0001658545,0.0006819726,0.9696962,0.0002649509,0.00001051853,0.005291493],"study_design_scores_gemma":[0.00003208119,0.001220084,0.45595,0.00002015368,0.0001303464,0.001098656,0.0004459818,0.009052293,0.5286304,0.0007201452,0.002654384,0.00004545775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969049,0.000271644,0.002191126,0.00002161656,0.000001980206,0.00001096672,0.0000765484,0.00001053481,0.0005105417],"genre_scores_gemma":[0.9977185,0.00009250479,0.001884946,0.00002524704,0.000002264969,0.00001249375,0.0001080067,0.000007088074,0.0001490557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362163,"threshold_uncertainty_score":0.006531358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00963366694989886,"score_gpt":0.2179966792255947,"score_spread":0.2083630122756959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}