{"id":"W2340373989","doi":"10.1534/genetics.115.183889","title":"Functional Divergence of the Nuclear Receptor<i>NR2C1</i>as a Modulator of Pluripotentiality During Hominid Evolution","year":2016,"lang":"en","type":"article","venue":"Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Division of Graduate Education; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Tula Foundation; George Washington University; James S. McDonnell Foundation; National Institutes of Health; National Science Foundation","keywords":"Biology; Natural selection; Gene; Induced pluripotent stem cell; Evolutionary biology; Gene regulatory network; Phenotype; Genetics; Functional divergence; Cellular differentiation; Genetic Fitness; Computational biology; Embryonic stem cell; Gene expression; Selection (genetic algorithm); Gene family","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532638,0.0001092401,0.0001186354,0.00003138898,0.00008235819,0.000004228761,0.0003236135,0.0001196562,0.0001489486],"category_scores_gemma":[0.0000981175,0.00007412377,0.0001378801,0.0001124347,0.0002443278,0.00000348715,0.0004196427,0.00005202094,0.0000304215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003252937,"about_ca_system_score_gemma":0.0000999796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000175375,"about_ca_topic_score_gemma":0.000009453593,"domain_scores_codex":[0.9987748,0.00009528548,0.0002662477,0.0002733331,0.0003750849,0.0002153067],"domain_scores_gemma":[0.9990395,0.000009629331,0.0001502679,0.0005302192,0.0002061566,0.00006425926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001243037,0.00005202261,0.02043407,0.00003542579,0.00004436354,2.108333e-7,0.0000152799,0.0001534475,0.9780174,0.00005975737,0.0008062521,0.0002575049],"study_design_scores_gemma":[0.0004432984,0.0000979898,0.1392907,0.00002639399,0.00001304235,0.00000563249,0.0000166108,0.00002619031,0.8573328,0.00009820142,0.002557932,0.00009121043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980757,0.0003176145,0.0007726545,0.0001578593,0.0002902433,0.0001662803,0.00007325682,0.000005354071,0.0001410743],"genre_scores_gemma":[0.9981259,0.0002586649,0.0002843019,0.00001237933,0.0001237782,0.0000046159,0.00000634228,0.00001740901,0.001166613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1206846,"threshold_uncertainty_score":0.302268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00963366694989886,"score_gpt":0.2179966792255947,"score_spread":0.2083630122756959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}