{"id":"W2340444741","doi":"10.1371/journal.ppat.1005545","title":"A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Maple Leaf Medical Clinic","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Ontario HIV Treatment Network; Ragon Institute of MGH, MIT and Harvard; Gilead Sciences; amfAR, The Foundation for AIDS Research; Howard Hughes Medical Institute","keywords":"Reversing; Cytotoxic T cell; Human immunodeficiency virus (HIV); Latency (audio); Immunology; Biology; Neuroscience; Cell biology; Computer science; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000157208,0.0001816885,0.0002644307,0.0001516525,0.0001642813,0.000008548776,0.0001420681,0.0001513539,0.0008571523],"category_scores_gemma":[0.0003152596,0.0001327707,0.00008834701,0.000195661,0.0000904657,0.00008000735,0.00008353827,0.00008567759,0.005245297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001627686,"about_ca_system_score_gemma":0.00007449301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004345618,"about_ca_topic_score_gemma":0.00001601062,"domain_scores_codex":[0.998517,0.0002625044,0.0002882974,0.0003465097,0.00007574684,0.0005099084],"domain_scores_gemma":[0.9991392,0.0002688329,0.0001047818,0.0002690199,0.0001314906,0.00008665922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001825661,0.0003645473,0.007351884,0.00002153889,0.0001692751,0.00003695468,0.0002786719,2.806178e-7,0.9777266,0.000001648095,0.004110246,0.009755762],"study_design_scores_gemma":[0.002167964,0.0004318831,0.002694959,0.0002707776,0.00006321855,0.00001711588,0.00006511064,0.000001500605,0.992733,0.00002853987,0.001351305,0.0001746521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956738,0.0002950476,0.0001177699,0.0001414241,0.0001029191,0.0004698644,0.002696909,0.00007731174,0.0004249656],"genre_scores_gemma":[0.9976233,0.0001385768,0.0004599265,0.00004194397,0.00001633024,0.00005699516,0.0005088295,0.00002394887,0.001130097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01500635,"threshold_uncertainty_score":0.9955292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03315270954045949,"score_gpt":0.2471362829971494,"score_spread":0.2139835734566899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}