{"id":"W2340491975","doi":"10.1021/acsbiomaterials.5b00496","title":"Human Stem Cell-Derived Cardiac Model of Chronic Drug Exposure","year":2016,"lang":"en","type":"article","venue":"ACS Biomaterials Science & Engineering","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Heart and Stroke Foundation; University of Toronto; Discovery Centre; University Health Network","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Angiotensin II; Endothelin receptor; Internal medicine; Endothelin 1; Brain natriuretic peptide; Endocrinology; Atrial natriuretic peptide; Renin–angiotensin system; Medicine; Biology; Heart failure; Blood pressure; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003639714,0.0004011883,0.000402495,0.0003788596,0.0002565259,0.0003256075,0.000281966,0.0005580061,0.003143039],"category_scores_gemma":[0.0001193718,0.0001541655,0.0003720158,0.000357625,0.0004059355,0.0001940802,0.0002829045,0.001092871,0.0006399716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046593,"about_ca_system_score_gemma":0.0003083313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002871154,"about_ca_topic_score_gemma":0.0004961896,"domain_scores_codex":[0.9997576,0.00003395209,0.00002859953,0.00006577373,0.00008801826,0.00002597892],"domain_scores_gemma":[0.999869,0.00002494345,0.00002881556,0.00003084488,0.00001472038,0.00003171681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005186694,0.0004182798,0.0005400447,0.0001084417,0.00002569573,0.0004222032,0.0000648572,0.0002134471,0.9933233,0.0004372356,0.0004242487,0.003503621],"study_design_scores_gemma":[0.0002809805,0.008419096,0.01047572,0.00004185649,0.0001483412,0.00232934,0.0001197959,0.002773543,0.9493568,0.0004365462,0.02558804,0.00002993166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680439,0.002662834,0.01918172,0.0004175559,0.0003854497,0.0007381135,0.002402776,0.0002213804,0.005946237],"genre_scores_gemma":[0.9742552,0.002897986,0.01006444,0.0004267113,0.00007871239,0.001028775,0.004429725,0.0000356545,0.006782684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003143039,"threshold_uncertainty_score":0.0105145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112857212761986,"score_gpt":0.2346222054013785,"score_spread":0.2234936332737586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}