{"id":"W2340491975","doi":"10.1021/acsbiomaterials.5b00496","title":"Human Stem Cell-Derived Cardiac Model of Chronic Drug Exposure","year":2016,"lang":"en","type":"article","venue":"ACS Biomaterials Science & Engineering","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Heart and Stroke Foundation; University of Toronto; Discovery Centre; University Health Network","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Angiotensin II; Endothelin receptor; Internal medicine; Endothelin 1; Brain natriuretic peptide; Endocrinology; Atrial natriuretic peptide; Renin–angiotensin system; Medicine; Biology; Heart failure; Blood pressure; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005993363,0.0001659337,0.0002007286,0.0001169242,0.00009241063,0.00004206677,0.0005963721,0.00007725855,0.000007660267],"category_scores_gemma":[0.00001838458,0.0001253086,0.00006241061,0.0001630632,0.0002257389,0.00002259784,0.000340827,0.00001784922,0.00001165164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007091809,"about_ca_system_score_gemma":0.0001793483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009325201,"about_ca_topic_score_gemma":9.096835e-7,"domain_scores_codex":[0.9984639,0.00002576575,0.0002666175,0.0004204497,0.0003394529,0.0004838415],"domain_scores_gemma":[0.9991825,0.000007171653,0.00007845267,0.0005018468,0.0001090358,0.0001209692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004684649,0.0000154297,0.00006073681,0.00003891927,0.000008481677,7.989613e-7,0.00003637006,0.002627564,0.9969434,0.00004417304,0.00004616907,0.0001732822],"study_design_scores_gemma":[0.0002384881,0.00009210979,0.000311301,0.00004047823,0.000005056119,0.000001346802,0.0000120054,0.0004047142,0.998566,0.000003282022,0.0001496554,0.0001755506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973227,0.0003498809,0.001717909,0.000026364,0.0002720494,0.0001756363,0.00004015695,0.00002957804,0.0000657186],"genre_scores_gemma":[0.9991024,0.0000973872,0.0003058423,0.000003395633,0.0001189306,0.00002257275,0.000005919691,0.00002437945,0.0003192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00222285,"threshold_uncertainty_score":0.5109937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112857212761986,"score_gpt":0.2346222054013785,"score_spread":0.2234936332737586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}