{"id":"W2340645480","doi":"10.1080/15592294.2016.1172161","title":"The characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatin","year":2016,"lang":"en","type":"article","venue":"Epigenetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Biology; Histone; Chromatin; Genetics; Evolutionary biology; Epigenetics; Histone-modifying enzymes; Nucleosome; Vertebrate; Histone code; Heterochromatin; Histone methylation; Lineage (genetic); Computational biology; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031471,0.0001345114,0.0001143264,0.0003115281,0.0002320634,0.0002957151,0.0001689608,0.0002099926,0.001303019],"category_scores_gemma":[0.0001537724,0.00008053864,0.0002004862,0.0002509888,0.0002461049,0.0002852934,0.0002225511,0.0002709533,0.0003011933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396798,"about_ca_system_score_gemma":0.0001545137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000893899,"about_ca_topic_score_gemma":0.00233748,"domain_scores_codex":[0.9999511,0.000002387025,0.000002648685,0.00002783806,0.000009382742,0.000006554964],"domain_scores_gemma":[0.9998094,0.00003291529,0.00005823682,0.00003089635,0.00002322285,0.00004525443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009989194,0.000007358966,0.02536579,0.00008389113,0.00003470546,0.0002692387,0.00006904783,0.0001534013,0.9641576,0.000725254,0.00005224784,0.008981628],"study_design_scores_gemma":[0.000009029672,0.0002310369,0.5966108,0.00003447646,0.0000836667,0.003894669,0.0001818312,0.001538263,0.3731298,0.001650387,0.02260208,0.00003387182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787701,0.003762692,0.01290267,0.0001433252,0.00003790829,0.0000120211,0.0009460088,0.00009803076,0.003327245],"genre_scores_gemma":[0.9927807,0.0006608981,0.004585122,0.00007178382,0.00002348594,0.00000561146,0.0006296265,0.00001554794,0.001227192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303019,"threshold_uncertainty_score":0.004359007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007194261839478701,"score_gpt":0.2457425486875605,"score_spread":0.2385482868480819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}