{"id":"W2340656051","doi":"10.1126/science.aap8757","title":"Analysis of shared heritability in common disorders of the brain","year":2018,"lang":"en","type":"article","venue":"Science","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2028,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Calgary; BC Mental Health & Substance Use Services; Montreal Neurological Institute and Hospital; Dalhousie University; University of Toronto; SickKids Foundation; Douglas Mental Health University Institute; McGill University; Centre Hospitalier de l’Université de Montréal; University of British Columbia; Hospital for Sick Children; University Health Network; Occupational Cancer Research Centre","funders":"National Institute of Mental Health; Institute of Zoology, Chinese Academy of Sciences; Menzies Centre for Australian Studies, King's College London, University of London; NIHR Maudsley Biomedical Research Centre; State University of New York Upstate Medical University; National Institutes of Health; Novo Nordisk Fonden; Universitätsklinikum Jena; Lee Kong Chian School of Medicine, Nanyang Technological University; State University of New York; Lundbeckfonden; Chinese University of Hong Kong; Virginia Commonwealth University; Vetenskapsrådet; Agence Nationale de la Recherche; Universiteit Maastricht; National Center for Advancing Translational Sciences; Medical Research Council; University of Wollongong; Oxford Health NHS Foundation Trust; Nanyang Technological University; Uniklinikum Giessen und Marburg; King's College London; National Institute of Neurological Disorders and Stroke; Syracuse University; Kunming Institute of Zoology, Chinese Academy of Sciences; NSW Health Pathology; National University of Singapore; Wellcome Trust; University College London; University of California, Santa Barbara; Royal College of Surgeons in Ireland; Chinese Academy of Sciences; University of Oxford; Lawrence Berkeley National Laboratory; Motor Neurone Disease Association; University of North Carolina at Chapel Hill; Parkinson's UK; NorthShore University HealthSystem; National Institute on Aging; National Institute for Health and Care Research","keywords":"Heritability; Genome-wide association study; Missing heritability problem; Etiology; Genetic association; Comorbidity; Twin study; Epidemiology; Psychiatry; Phenotype; Medicine; Clinical psychology; Psychology; Biology; Genetics; Genetic variants; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007310837,0.0004982862,0.0008024464,0.001769083,0.0005604946,0.0008600631,0.00054987,0.0004775788,0.001407806],"category_scores_gemma":[0.02434137,0.0003914398,0.001081923,0.001832913,0.001327846,0.0007407597,0.00150705,0.0006789177,0.00009688989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003984261,"about_ca_system_score_gemma":0.0004529931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004148853,"about_ca_topic_score_gemma":0.003430906,"domain_scores_codex":[0.9936478,0.003813307,0.0003299198,0.001398802,0.0005165091,0.0002938305],"domain_scores_gemma":[0.9808647,0.01325973,0.002370005,0.002843195,0.0003924674,0.0002699857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002294555,0.00002800394,0.9776715,0.0000355252,0.002106421,0.0005059835,0.0004287877,0.007044908,0.001810418,0.002768568,0.0001200372,0.007250375],"study_design_scores_gemma":[0.00003698052,0.0001406106,0.9591443,0.00003015647,0.0009555009,0.0009442501,0.0003613153,0.0288394,0.0008011485,0.008316711,0.0004005847,0.00002904941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919962,0.0002394808,0.007091444,0.00008110802,0.000005619466,0.00001312798,0.0002745556,0.00002361101,0.0002747015],"genre_scores_gemma":[0.9989747,0.00004530854,0.0008259594,0.000007061959,0.000003750692,0.000005987865,0.000108556,0.000005029042,0.00002379146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007310837,"threshold_uncertainty_score":0.03866386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036892081720274,"score_gpt":0.2946172120931,"score_spread":0.2842482912758972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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