{"id":"W2340702357","doi":"10.1371/journal.ppat.1005494","title":"An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Israel Science Foundation","keywords":"Arginine; Leishmania; Intracellular; Biology; Phagolysosome; Cell biology; Intracellular parasite; Macrophage; Extracellular; Leishmania major; Amino acid; Amino acid transporter; Arginase; Arginine kinase; Biochemistry; Transporter; Parasite hosting; Gene; Phagosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008554664,0.0002512541,0.0004180815,0.0004998101,0.0001419384,0.00002941058,0.0001969691,0.0001678923,0.0002754331],"category_scores_gemma":[0.001899845,0.0001795416,0.00008334291,0.0004879805,0.00007286651,0.0003209971,0.0001599421,0.0002843946,0.000274723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003714502,"about_ca_system_score_gemma":0.000153423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002617038,"about_ca_topic_score_gemma":0.00006247964,"domain_scores_codex":[0.9972627,0.0003825733,0.0004549543,0.0006238982,0.0006858089,0.0005900213],"domain_scores_gemma":[0.9983438,0.0002387725,0.0001084785,0.0008015127,0.0002248419,0.0002825894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001612746,0.0003597909,0.1637888,0.00005613188,0.00003465401,0.0006847865,0.0009915876,2.505012e-7,0.8283392,0.00001405375,0.00005725802,0.004060702],"study_design_scores_gemma":[0.001932894,0.0004176795,0.5357361,0.0002485668,0.00001260038,0.00002429353,0.0001386525,0.00002917964,0.4611782,0.00003174925,0.0001119924,0.0001381018],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956004,0.00007931398,0.00002372803,0.003045391,0.00005679941,0.0007036611,0.0000579689,0.0001391766,0.0002935694],"genre_scores_gemma":[0.9980727,0.0001697433,0.0005037902,0.0002536724,0.0001640951,0.0001109672,0.00001129017,0.00006548028,0.0006482737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3719472,"threshold_uncertainty_score":0.7321495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04580428568671191,"score_gpt":0.299021911029148,"score_spread":0.2532176253424361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}