{"id":"W2340892846","doi":"10.1038/srep22311","title":"Sequence evidence for common ancestry of eukaryotic endomembrane coatomers","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Science for Life Laboratory; Canadian Institutes of Health Research; European Commission","keywords":"Endomembrane system; COPII; Intraflagellar transport; Nucleoporin; Biology; Nuclear pore; Superhelix; Computational biology; Sequence space; Sequence motif; COPI; Cell biology; Evolutionary biology; Genetics; RNA; Cell nucleus; Cytoplasm; DNA; Nuclear transport; Gene; Cell; Golgi apparatus; DNA supercoil; Secretory pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602181,0.000167325,0.0002323727,0.0005470408,0.0003649346,0.0003349214,0.00017733,0.0003021631,0.001562455],"category_scores_gemma":[0.0005312989,0.0001222786,0.0002455298,0.0005332487,0.0003478698,0.0001697157,0.000367702,0.0002970242,0.0005856638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001562508,"about_ca_system_score_gemma":0.0002112435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004218082,"about_ca_topic_score_gemma":0.0006540973,"domain_scores_codex":[0.9998622,0.00001763682,0.00001510035,0.00005060844,0.00003175911,0.00002270419],"domain_scores_gemma":[0.9993204,0.0001516197,0.0001391024,0.0001125945,0.000106953,0.0001692689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007979312,0.00005983559,0.0614442,0.0001725514,0.000127055,0.001855083,0.0005433806,0.0002476581,0.920679,0.002217421,0.0001823088,0.01167368],"study_design_scores_gemma":[0.00007001979,0.0007166581,0.8417286,0.00007455743,0.0003486013,0.009169011,0.0005362325,0.002529702,0.1247473,0.002886784,0.01713265,0.00005988738],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934943,0.0005658187,0.003125027,0.00004747904,0.00002074211,0.00001492947,0.0004514115,0.00003152815,0.002248672],"genre_scores_gemma":[0.996237,0.0002063084,0.00198461,0.00004808729,0.00002009405,0.000008098479,0.001059942,0.0000102954,0.0004254715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562455,"threshold_uncertainty_score":0.00522691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06070140371155875,"score_gpt":0.3317337500901887,"score_spread":0.27103234637863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}