{"id":"W2341109405","doi":"10.1016/j.jri.2016.04.284","title":"Certolizumab pegol does not bind the neonatal Fc receptor (FcRn): Consequences for FcRn-mediated in vitro transcytosis and ex vivo human placental transfer","year":2016,"lang":"en","type":"article","venue":"Journal of Reproductive Immunology","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; Valeant Pharmaceuticals International","keywords":"Certolizumab pegol; Adalimumab; Infliximab; Neonatal Fc receptor; Transcytosis; Antibody-dependent cell-mediated cytotoxicity; Ex vivo; Pharmacology; In vivo; Placenta; Medicine; Immunology; Tumor necrosis factor alpha; Antibody; Fetus; Biology; Immunoglobulin G; Receptor; Internal medicine; Monoclonal antibody; Pregnancy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004334728,0.0001935858,0.0005434986,0.0002541961,0.0001125915,0.00001042079,0.0001879385,0.0001612882,0.0001766272],"category_scores_gemma":[0.0007947164,0.00009157662,0.0001599931,0.0001407171,0.001099285,0.0002536336,0.00001526746,0.0003387716,0.000003861224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229681,"about_ca_system_score_gemma":0.0002711037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002731108,"about_ca_topic_score_gemma":0.00001701781,"domain_scores_codex":[0.9982299,0.0002187815,0.0006430013,0.0003552377,0.0002269625,0.0003261837],"domain_scores_gemma":[0.9986541,0.0004909098,0.000249676,0.0003071715,0.0001987367,0.00009945536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00896968,0.000142308,0.001622888,0.00003326984,0.000369129,0.00005735565,0.002501709,7.723472e-8,0.963636,0.00004461959,0.0001767493,0.02244624],"study_design_scores_gemma":[0.008929166,0.001807992,0.01231277,0.0003909705,0.0001735121,0.004428222,0.001692711,7.53801e-7,0.9605536,0.0002000379,0.009353064,0.000157182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588155,0.004992052,0.0002811652,0.03427627,0.0006248861,0.0007899718,0.000157711,0.00001458944,0.00004793229],"genre_scores_gemma":[0.9966331,0.002368767,0.0001549954,0.0001164029,0.0003164622,0.00005081532,0.000009970987,0.00001993352,0.0003296134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03781761,"threshold_uncertainty_score":0.4050362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800770183065488,"score_gpt":0.2807979884358244,"score_spread":0.2627902866051695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}