{"id":"W2341298585","doi":"10.1158/1538-7445.sabcs15-pd5-03","title":"Abstract PD5-03: Prophylactic beta blockade preserves left ventricular ejection fraction in HER2-overexpresssing breast cancer patients receiving trastuzumab: Primary results of the MANTICORE randomized controlled trial","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; University of Alberta","funders":"","keywords":"Medicine; Ejection fraction; Heart failure; Internal medicine; Cardiology; Trastuzumab; Breast cancer; Ventricular remodeling; Asymptomatic; Bisoprolol; Perindopril; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001658023,0.001305506,0.002056733,0.000259491,0.0002946423,0.001262974,0.000840965,0.001310069,0.004318807],"category_scores_gemma":[0.001601345,0.0004290023,0.001529314,0.0003108131,0.0008727766,0.0006565374,0.0002978386,0.002165091,0.0005734379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005473648,"about_ca_system_score_gemma":0.0006253604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006297061,"about_ca_topic_score_gemma":0.001197981,"domain_scores_codex":[0.9993711,0.0003383086,0.00004963118,0.0001288254,0.00004879797,0.00006331038],"domain_scores_gemma":[0.9990007,0.0003037628,0.0002760589,0.00008729532,0.00006688704,0.0002652446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9852338,0.002354485,0.001609039,0.0004403362,0.001304705,0.00003401627,0.000022264,0.0001695085,0.001573371,0.00007053735,0.0006111583,0.006576765],"study_design_scores_gemma":[0.9562669,0.03454771,0.005982493,0.00004589338,0.001804034,0.00004696679,0.00001802779,0.0004071091,0.0003320361,0.0001100962,0.0004243054,0.00001441418],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888746,0.005775498,0.0002489199,0.0005950033,0.0002779624,0.001083933,0.0009015094,0.00006718963,0.002175397],"genre_scores_gemma":[0.993343,0.001579801,0.0005637861,0.0008841038,0.000498641,0.0007271618,0.001160554,0.000009045399,0.001233918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004318807,"threshold_uncertainty_score":0.01444781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02683938508236482,"score_gpt":0.3282862190332369,"score_spread":0.3014468339508721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}