{"id":"W2341414956","doi":"10.2337/dc15-1988","title":"Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia","year":2016,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":635,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Sanofi; National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Sanofi Genzyme; University of Illinois at Urbana-Champaign; National Institutes of Health; University of California, San Francisco; Novo Nordisk Fonden; Uppsala Universitet; University of Pennsylvania; Novo Nordisk; University of Minnesota; Wyeth Pharmaceuticals; University of Miami; Pfizer; Northwestern University; Eli Lilly and Company; Pfizer Pharmaceuticals; Immune Tolerance Network; Astellas Pharma US; LifeScan; National Center for Advancing Translational Sciences; Johnson and Johnson; Emory University","keywords":"Medicine; Hypoglycemia; Diabetes mellitus; Type 1 diabetes; Islet; Transplantation; Type 2 diabetes; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009417043,0.0001484942,0.0005105088,0.0001499344,0.00002148753,0.000003322273,0.00007728223,0.0001165347,0.0002087099],"category_scores_gemma":[0.0001263523,0.000108886,0.00009291581,0.0002595721,0.0001059619,0.00006672613,0.00001000396,0.00007050389,0.00002481854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004699379,"about_ca_system_score_gemma":0.00004419379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008591307,"about_ca_topic_score_gemma":0.00000121617,"domain_scores_codex":[0.9988559,0.00005798387,0.0004328256,0.0002120727,0.0002089052,0.0002323383],"domain_scores_gemma":[0.9991139,0.0002136734,0.000150652,0.0002474458,0.0001899166,0.0000843788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003783521,0.0004290291,0.1332957,0.0004415485,0.00005964756,0.000001176447,0.0002959192,3.49753e-7,0.8546904,0.00002264106,0.001140117,0.005840017],"study_design_scores_gemma":[0.1095636,0.004272169,0.01034056,0.0006444153,0.0001795467,3.317423e-7,0.0001664406,0.00001778095,0.874097,0.0000708475,0.0004791256,0.0001682155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996695,0.000497763,0.000002389802,0.00009890627,0.0001231694,0.0004564784,0.0003534253,0.00003727712,0.001735586],"genre_scores_gemma":[0.9990906,0.00005177432,0.00004078434,0.0001071394,0.00004096228,0.00003053688,0.0005280696,0.00001958459,0.00009051171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1229551,"threshold_uncertainty_score":0.4440241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781497925833954,"score_gpt":0.2824424355140206,"score_spread":0.2646274562556811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}