{"id":"W2341414956","doi":"10.2337/dc15-1988","title":"Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia","year":2016,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":635,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Sanofi; National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Sanofi Genzyme; University of Illinois at Urbana-Champaign; National Institutes of Health; University of California, San Francisco; Novo Nordisk Fonden; Uppsala Universitet; University of Pennsylvania; Novo Nordisk; University of Minnesota; Wyeth Pharmaceuticals; University of Miami; Pfizer; Northwestern University; Eli Lilly and Company; Pfizer Pharmaceuticals; Immune Tolerance Network; Astellas Pharma US; LifeScan; National Center for Advancing Translational Sciences; Johnson and Johnson; Emory University","keywords":"Medicine; Hypoglycemia; Diabetes mellitus; Type 1 diabetes; Islet; Transplantation; Type 2 diabetes; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003033711,0.001162383,0.001255152,0.0002340729,0.0003923123,0.0007403666,0.0007824976,0.001062093,0.002734772],"category_scores_gemma":[0.001639562,0.0003326988,0.001299364,0.0002856865,0.0005888686,0.0005090577,0.0004020475,0.002816896,0.0003484717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004870282,"about_ca_system_score_gemma":0.00170292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006088666,"about_ca_topic_score_gemma":0.001114968,"domain_scores_codex":[0.9992679,0.0004685003,0.00002902983,0.00008775677,0.00005633288,0.00009050009],"domain_scores_gemma":[0.9988899,0.0002664303,0.0002931342,0.0001059723,0.00007458314,0.0003700955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8747644,0.04258074,0.009508357,0.0005752669,0.001481836,0.0002778606,0.0001409025,0.00204516,0.010773,0.0002044405,0.002604136,0.05504385],"study_design_scores_gemma":[0.6538641,0.3323588,0.01019743,0.00003713842,0.0002743515,0.0001841834,0.00003229966,0.0008805673,0.001095098,0.0001566353,0.000906289,0.00001318455],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933413,0.001602729,0.0006477589,0.0004313737,0.0001414824,0.002289045,0.0005484722,0.00006461143,0.000933215],"genre_scores_gemma":[0.988363,0.001252385,0.002186736,0.001318659,0.0002368152,0.004055392,0.001486146,0.00002103758,0.001079794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003033711,"threshold_uncertainty_score":0.01604402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781497925833954,"score_gpt":0.2824424355140206,"score_spread":0.2646274562556811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}