{"id":"W2341556921","doi":"10.1161/circep.116.004003","title":"Dissociative States: hERG Channel (Kv11.1) Modulators That Enhance Dissociation of Drugs From Their Blocking Receptor","year":2016,"lang":"en","type":"letter","venue":"Circulation Arrhythmia and Electrophysiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"","keywords":"hERG; Medicine; Blocking (statistics); Pharmacology; Dissociation (chemistry); Biophysics; Internal medicine; Potassium channel; Chemistry; Computer network; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001545085,0.0007084191,0.001741467,0.0002713802,0.0002585772,0.00001847413,0.0001260821,0.001536783,0.0001368095],"category_scores_gemma":[0.0001083017,0.0005658265,0.0005325709,0.0002792346,0.0003658255,0.0001599385,0.00007469341,0.001426794,0.00004326624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004139652,"about_ca_system_score_gemma":0.0002109273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006950822,"about_ca_topic_score_gemma":0.000002345233,"domain_scores_codex":[0.996409,0.0004673536,0.0007047976,0.001119675,0.0003710562,0.000928101],"domain_scores_gemma":[0.9972296,0.0006912428,0.001096003,0.0005464486,0.0003166157,0.0001201373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002185065,0.0001082754,0.000949003,0.0006535373,0.006294583,0.0003674913,0.007087271,0.000335547,0.8523117,0.0002604549,0.09319462,0.03625244],"study_design_scores_gemma":[0.01722604,0.007087039,0.171979,0.006161393,0.006194824,0.0007614407,0.001614472,0.008462656,0.3440277,0.1761707,0.2495353,0.01077939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.895178,0.001525051,0.0006841696,0.1004626,0.0006927772,0.0007994119,0.0004053236,0.0001355115,0.0001171232],"genre_scores_gemma":[0.9506043,0.002125645,0.00005396987,0.03385179,0.009218856,0.0001093052,0.003393445,0.0001277024,0.0005149842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.508284,"threshold_uncertainty_score":0.9997594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008312795989480657,"score_gpt":0.2334278727955318,"score_spread":0.2251150768060511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}