{"id":"W2341568259","doi":"10.1200/jco.2011.29.7_suppl.22","title":"Utilizing metformin to enhance the efficacy of androgen-deprivation therapy in the treatment of prostate cancer.","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Health Sciences Centre; University Health Network; Sunnybrook Health Science Centre","funders":"","keywords":"DU145; Bicalutamide; Metformin; Hyperinsulinemia; LNCaP; Prostate cancer; Medicine; Endocrinology; Internal medicine; Cancer research; In vivo; Cancer; Cell growth; Pharmacology; Insulin; Androgen receptor; Insulin resistance; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002399873,0.0003596531,0.0003874272,0.000412874,0.0001865627,0.00044556,0.0004408281,0.0003356753,0.001752407],"category_scores_gemma":[0.000113812,0.0001316214,0.0004217254,0.0003093616,0.0001702085,0.000284725,0.0002639251,0.0008140892,0.0003552738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002920996,"about_ca_system_score_gemma":0.0004256443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007852734,"about_ca_topic_score_gemma":0.004045711,"domain_scores_codex":[0.9998965,0.00002145749,0.00001061636,0.00001708506,0.00003029811,0.00002401784],"domain_scores_gemma":[0.9999404,0.000007727319,0.00001734814,0.000005093106,0.000007271386,0.00002207493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005063331,0.003573457,0.002079694,0.001322231,0.0002280661,0.0005011312,0.00009196049,0.00128819,0.8287918,0.0007060225,0.002225195,0.154129],"study_design_scores_gemma":[0.003152916,0.05612673,0.03754784,0.0001726829,0.000758211,0.002749962,0.0001082969,0.003962846,0.8411353,0.0003444936,0.05385304,0.00008763654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626508,0.02796576,0.001593664,0.0006534005,0.0002931793,0.0003431996,0.0006445498,0.0001345432,0.005720984],"genre_scores_gemma":[0.9833229,0.01106901,0.002087514,0.0002018009,0.00008747096,0.000119204,0.0006642378,0.00001774579,0.002430092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752407,"threshold_uncertainty_score":0.005862355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1236346540135075,"score_gpt":0.4527144978906402,"score_spread":0.3290798438771326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}