{"id":"W2341648636","doi":"10.1097/fpc.0000000000000222","title":"Disposition kinetics and metabolism of nicotine and cotinine in African American smokers","year":2016,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Center for Research Resources; National Institute on Drug Abuse","keywords":"Cotinine; CYP2A6; Nicotine; Metabolite; Pharmacokinetics; Urine; Chemistry; Pharmacology; Metabolism; Genotype; Excretion; Internal medicine; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499157,0.000174548,0.0002488517,0.00006253913,0.00002738891,0.00001017071,0.00008359669,0.00005146143,0.000004814998],"category_scores_gemma":[0.00003065929,0.0001435005,0.00002796126,0.0000846846,0.0003342684,0.000003179269,0.0002116221,0.00005376287,3.520825e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009348534,"about_ca_system_score_gemma":0.0000213701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003343012,"about_ca_topic_score_gemma":0.0000423693,"domain_scores_codex":[0.9990307,0.00005278382,0.0002882707,0.0003357426,0.00007615813,0.0002163505],"domain_scores_gemma":[0.9995005,0.000030694,0.0001462604,0.0001497502,0.00004780455,0.0001249578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009828175,0.00006932453,0.02904008,0.00001423733,0.00004858842,1.900299e-7,0.0001080205,0.000005851949,0.9303523,0.00003499459,0.00004233991,0.04018582],"study_design_scores_gemma":[0.003300072,0.0004785199,0.06177894,0.00001934997,0.0001248471,0.00002294131,0.0001903857,0.0001526313,0.9083384,0.00006236562,0.02515639,0.000375118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948092,0.004034703,0.000337435,0.000398307,0.00006299921,0.0001910775,0.00008020509,0.000004045885,0.00008202788],"genre_scores_gemma":[0.9797763,0.01829126,0.001617262,0.0001097734,0.0001103621,0.000008092358,0.00001374996,0.00002611909,0.00004709047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0398107,"threshold_uncertainty_score":0.585178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006653470320758963,"score_gpt":0.2551954075679669,"score_spread":0.248541937247208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}