{"id":"W2341667536","doi":"10.1038/nmicrobiol.2015.2","title":"Crystal structure of Clostridium difficile toxin A","year":2016,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Argonne National Laboratory; Basic Energy Sciences; National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Michigan Technology Tri-Corridor; Office of Science; National Institutes of Health; Brookhaven National Laboratory; U.S. Department of Veterans Affairs; U.S. Department of Energy","keywords":"Clostridium difficile toxin B; Pore-forming toxin; Clostridium difficile; Endosome; Glucosyltransferase; Clostridium difficile toxin A; Pseudomembranous colitis; Peptide sequence; Biology; GTPase; Anthrax toxin; Hydrolase; Proteolysis; Biochemistry; Toxin; Chemistry; Microbiology; Cell biology; Enzyme; Microbial toxins; Receptor; Fusion protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743555,0.0003622119,0.0004506503,0.0002583934,0.000741432,0.0007541404,0.0005821133,0.0004604793,0.003794355],"category_scores_gemma":[0.0007005064,0.0001856239,0.0001773554,0.0005427201,0.000230821,0.0002603075,0.0002226555,0.001536355,0.0005554667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001152913,"about_ca_system_score_gemma":0.001502396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0104046,"about_ca_topic_score_gemma":0.009726918,"domain_scores_codex":[0.999884,0.00001558169,0.000005481689,0.00001884677,0.00004846192,0.0000275795],"domain_scores_gemma":[0.9998065,0.00005100694,0.0000264266,0.000007654467,0.00005591902,0.00005250141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004412521,0.001648262,0.02168863,0.002347284,0.0003888654,0.006707957,0.001130544,0.03909016,0.5756376,0.04497324,0.2197428,0.08223207],"study_design_scores_gemma":[0.003323151,0.0027401,0.08440294,0.0005993129,0.0004442887,0.005318883,0.003078354,0.1731045,0.1979079,0.0207132,0.5080137,0.0003537203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9345545,0.01203507,0.004962998,0.005623352,0.002448421,0.00008974297,0.007570222,0.000478921,0.03223678],"genre_scores_gemma":[0.9594697,0.006193938,0.004542594,0.000825135,0.0001871937,0.00006172474,0.01448219,0.00004931527,0.01418816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0104046,"threshold_uncertainty_score":0.02068806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00879315714340416,"score_gpt":0.27196272466027,"score_spread":0.2631695675168659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}