{"id":"W2341667536","doi":"10.1038/nmicrobiol.2015.2","title":"Crystal structure of Clostridium difficile toxin A","year":2016,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Argonne National Laboratory; Basic Energy Sciences; National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Michigan Technology Tri-Corridor; Office of Science; National Institutes of Health; Brookhaven National Laboratory; U.S. Department of Veterans Affairs; U.S. Department of Energy","keywords":"Clostridium difficile toxin B; Pore-forming toxin; Clostridium difficile; Endosome; Glucosyltransferase; Clostridium difficile toxin A; Pseudomembranous colitis; Peptide sequence; Biology; GTPase; Anthrax toxin; Hydrolase; Proteolysis; Biochemistry; Toxin; Chemistry; Microbiology; Cell biology; Enzyme; Microbial toxins; Receptor; Fusion protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000111299,0.0002762646,0.0006109705,0.0002690083,0.00005432394,0.000006532793,0.0002547568,0.0009872192,0.001910434],"category_scores_gemma":[0.00037642,0.0001651292,0.0002323995,0.0003741106,0.0003484253,0.00003702336,0.0001584018,0.0007772128,0.0000638467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629422,"about_ca_system_score_gemma":0.0002898888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001502623,"about_ca_topic_score_gemma":0.00001896033,"domain_scores_codex":[0.998209,0.00008292834,0.0004295823,0.0005094591,0.0001762536,0.0005927543],"domain_scores_gemma":[0.9985939,0.0002193291,0.0001325098,0.0005676688,0.0003160203,0.0001705566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000662308,0.000160929,0.0008939692,0.00007300874,0.0001076805,0.00003756555,0.00002994537,2.153375e-7,0.9821203,0.0003684293,0.01304798,0.002497618],"study_design_scores_gemma":[0.002415873,0.000583864,0.000435319,0.0001092041,0.00005532338,0.0005419379,0.00003024667,0.000001035753,0.949956,0.000070478,0.04561932,0.0001814253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927049,0.001465018,0.00003463057,0.003003486,0.0003714154,0.0003978583,0.0008644172,0.00006514748,0.001093169],"genre_scores_gemma":[0.9973341,0.0001218133,0.000263346,0.0003073439,0.000384324,0.000004332831,0.0001264332,0.00003642632,0.001421945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03257134,"threshold_uncertainty_score":0.999002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00879315714340416,"score_gpt":0.27196272466027,"score_spread":0.2631695675168659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}