{"id":"W2341821042","doi":"10.1097/pai.0000000000000371","title":"New Robust and Reproducible Stereological IHC Ki67 Breast Cancer Proliferative Assessment to Replace Traditional Biased Labeling Index","year":2016,"lang":"en","type":"article","venue":"Applied immunohistochemistry & molecular morphology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"","keywords":"Immunohistochemistry; Concordance; Breast cancer; Medicine; Cytokeratin; Nottingham Prognostic Index; Progesterone receptor; Hormone receptor; Oncology; Estrogen receptor; Cancer; Proliferation index; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001893635,0.0004704494,0.0004382653,0.0000596974,0.0001855641,0.00002835054,0.0003032855,0.0003068596,0.0002656199],"category_scores_gemma":[0.00006325266,0.0003880892,0.0001029325,0.0001600145,0.0002869973,0.000008325915,0.0003525393,0.0001969164,0.00001317118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00031548,"about_ca_system_score_gemma":0.0004133798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001446655,"about_ca_topic_score_gemma":0.000002238071,"domain_scores_codex":[0.9972227,0.00006361451,0.0004046973,0.001516423,0.0002465378,0.0005460093],"domain_scores_gemma":[0.9984927,0.00004093369,0.0001817734,0.0008942971,0.0001486459,0.0002416267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007948088,0.0001064753,0.002666469,0.00001777374,0.0003196991,0.00003647715,0.00004532606,0.0001426322,0.9884107,0.0002222812,0.004037321,0.00320006],"study_design_scores_gemma":[0.004531896,0.0002691246,0.03706948,0.00008946204,0.0001502427,0.0008177328,0.000109843,0.000006605882,0.9548795,0.0003789727,0.0008032962,0.0008938737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717411,0.001101243,0.0200154,0.005047227,0.0001773755,0.0005949149,0.0002405206,0.00005949366,0.001022682],"genre_scores_gemma":[0.9881274,0.0001044187,0.008478445,0.001415108,0.0003016663,0.0006902007,0.0001688205,0.00005896222,0.0006549884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03440301,"threshold_uncertainty_score":0.9998571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745895271845879,"score_gpt":0.2738526914245756,"score_spread":0.2563937387061168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}