{"id":"W2341846550","doi":"10.1371/journal.pone.0153946","title":"Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Niagara Health System; Université de Montréal; St. Michael's Hospital; Hôpital du Sacré-Cœur de Montréal; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Tyrosine phosphorylation; Cell biology; Caspase 3; Caspase 8; Tyrosine; Biology; Tyrosine kinase; Caspase; Signal transduction; Chemistry; Apoptosis; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001945889,0.0004137608,0.0003788341,0.0001687451,0.0001319352,0.0002489217,0.000253481,0.0002736518,0.002331355],"category_scores_gemma":[0.0001522068,0.0001310482,0.0003396798,0.0001609138,0.0002232503,0.0001880936,0.0002035323,0.0009854176,0.0005104844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823472,"about_ca_system_score_gemma":0.0002983698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003955378,"about_ca_topic_score_gemma":0.0004475178,"domain_scores_codex":[0.999633,0.00004922587,0.00004853799,0.00004666999,0.0001145818,0.0001079786],"domain_scores_gemma":[0.9998331,0.00003235382,0.00004517486,0.0000321586,0.00001403357,0.00004306047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001444478,0.00009515265,0.00008024409,0.00004547562,0.000008605688,0.000052701,0.000008943738,0.00008412252,0.998118,0.0001588221,0.00005176375,0.001151668],"study_design_scores_gemma":[0.00002841547,0.0003595202,0.001132982,0.000004643908,0.00001035366,0.0002279393,0.000008699127,0.000857461,0.9959034,0.00003717187,0.001427125,0.000002334237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950352,0.001456136,0.001655806,0.0001000854,0.00005149291,0.00002590347,0.0002025928,0.00006567778,0.001407201],"genre_scores_gemma":[0.9964153,0.000623482,0.0008576362,0.00002803761,0.00001183556,0.0000278034,0.0003732379,0.00001066421,0.001652013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331355,"threshold_uncertainty_score":0.007799149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118709731759037,"score_gpt":0.2154819590382519,"score_spread":0.1942948617206615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}