{"id":"W2341868726","doi":"10.1093/jac/dkw109","title":"Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity","year":2016,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Dolutegravir; Raltegravir; Integrase; Integrase inhibitor; Mutant; Virology; Biology; Drug resistance; DNA; Mutation; Resistance mutation; Recombinant DNA; Genetics; Reverse transcriptase; Molecular biology; Virus; Gene; Viral load; Antiretroviral therapy; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127106,0.0004844797,0.000445885,0.0001798528,0.0001225881,0.0003612755,0.000405091,0.0003921279,0.003368155],"category_scores_gemma":[0.0003177114,0.0001720763,0.0003549923,0.0001547449,0.0004057128,0.0001403059,0.0002351719,0.0006350832,0.0007607337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007032,"about_ca_system_score_gemma":0.000221195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006401513,"about_ca_topic_score_gemma":0.0007398133,"domain_scores_codex":[0.9997352,0.00005591178,0.00003870403,0.00004416137,0.00007354099,0.00005251609],"domain_scores_gemma":[0.9997621,0.00005501489,0.0000934203,0.00002482285,0.00001495246,0.0000496542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001970861,0.0001331391,0.0004399699,0.00002954491,0.00001543016,0.0001296017,0.00001033615,0.00008967504,0.9981039,0.00004397584,0.00004260175,0.0007647065],"study_design_scores_gemma":[0.0001216307,0.001410754,0.01124285,0.00002584729,0.00004694506,0.001529131,0.00006638257,0.001532427,0.9822459,0.00004753781,0.001714921,0.00001561794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986628,0.0001293237,0.0004162067,0.00004050688,0.00001536125,0.00001514679,0.0001644297,0.00002953841,0.0005267212],"genre_scores_gemma":[0.9978319,0.000130362,0.0007487917,0.00005245902,0.000006963659,0.00001147724,0.0003009759,0.00003016009,0.0008868456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003368155,"threshold_uncertainty_score":0.01126766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003274056537508,"score_gpt":0.2413729964147769,"score_spread":0.2313402558494018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}