{"id":"W2341868726","doi":"10.1093/jac/dkw109","title":"Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity","year":2016,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Dolutegravir; Raltegravir; Integrase; Integrase inhibitor; Mutant; Virology; Biology; Drug resistance; DNA; Mutation; Resistance mutation; Recombinant DNA; Genetics; Reverse transcriptase; Molecular biology; Virus; Gene; Viral load; Antiretroviral therapy; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000322678,0.0002498752,0.0005357458,0.0004603615,0.00007208382,0.00003117977,0.0000908655,0.0001201881,0.000114147],"category_scores_gemma":[0.0001872045,0.0001558188,0.0001352301,0.0003081521,0.0001646785,0.0003087298,0.00001625412,0.0001893756,0.00001387746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993407,"about_ca_system_score_gemma":0.000326986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003408952,"about_ca_topic_score_gemma":0.00007217412,"domain_scores_codex":[0.9987115,0.0000794739,0.0004653346,0.0002209005,0.0002356343,0.0002871613],"domain_scores_gemma":[0.9989882,0.0001940465,0.0003476822,0.0001425737,0.0001167311,0.0002107604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004112447,0.0009308009,0.08503879,0.00004253973,0.0002536814,0.0005114361,0.0002403152,1.351004e-7,0.8984432,0.00004264505,0.006322751,0.004061315],"study_design_scores_gemma":[0.01897738,0.0002134325,0.08675655,0.003275502,0.0001639125,0.0008721672,0.00008579456,0.000004460135,0.883835,0.00006707742,0.005359301,0.0003894304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895498,0.0003131572,0.0002404836,0.009485042,0.00008465144,0.0002014038,0.00002787646,0.00002228079,0.00007534076],"genre_scores_gemma":[0.99435,0.002280949,0.001772182,0.000291405,0.0001413963,0.00000199213,0.00001342618,0.00002720231,0.001121468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01486493,"threshold_uncertainty_score":0.6354107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003274056537508,"score_gpt":0.2413729964147769,"score_spread":0.2313402558494018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}