{"id":"W2341875784","doi":"10.1371/journal.pbio.1002447","title":"Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation","year":2016,"lang":"en","type":"letter","venue":"PLoS Biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; University of Toronto","funders":"","keywords":"Amyotrophic lateral sclerosis; Biology; Hydrogen bond; Biophysics; Terminal (telecommunication); Protein aggregation; Electrostatics; Solubility; Static electricity; Domain (mathematical analysis); Plasma protein binding; Biochemistry; Cell biology; Chemical physics; Molecule; Chemistry; Physics; Disease; Physical chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001887459,0.0003851172,0.0007442119,0.0002217283,0.00009187122,0.00002151474,0.0002956493,0.001399999,0.001887972],"category_scores_gemma":[0.00029352,0.0002451071,0.0001895334,0.0001510169,0.0002887741,0.00005918382,0.0001549931,0.001752063,0.001122034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006010283,"about_ca_system_score_gemma":0.0002123995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006784561,"about_ca_topic_score_gemma":0.000006613821,"domain_scores_codex":[0.9968119,0.0004061334,0.0004927746,0.0007974664,0.0005004903,0.0009912966],"domain_scores_gemma":[0.9984044,0.0002961978,0.0002776696,0.0007149888,0.0001728173,0.0001339397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002909287,0.00005584365,0.002279151,0.0003037811,0.0002126353,0.001001415,0.00004240765,8.998051e-9,0.2057729,0.00003419089,0.7826236,0.007383055],"study_design_scores_gemma":[0.002163664,0.002467442,0.005516685,0.001213077,0.0001936754,0.0005297703,0.000005865298,0.00002552993,0.00356842,0.003680252,0.9800779,0.0005576969],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.172735,0.0002875873,0.0001114579,0.8233049,0.0002995349,0.0009975265,0.0001559772,0.0001319524,0.001976097],"genre_scores_gemma":[0.09335298,0.001493134,0.001744152,0.8398085,0.0226657,0.0004692649,0.004501853,0.0003158468,0.03564858],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2022045,"threshold_uncertainty_score":0.9998964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03066946943295058,"score_gpt":0.3046061692045168,"score_spread":0.2739366997715662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}