{"id":"W2341875784","doi":"10.1371/journal.pbio.1002447","title":"Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation","year":2016,"lang":"en","type":"letter","venue":"PLoS Biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; University of Toronto","funders":"","keywords":"Amyotrophic lateral sclerosis; Biology; Hydrogen bond; Biophysics; Terminal (telecommunication); Protein aggregation; Electrostatics; Solubility; Static electricity; Domain (mathematical analysis); Plasma protein binding; Biochemistry; Cell biology; Chemical physics; Molecule; Chemistry; Physics; Disease; Physical chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001756949,0.0002791918,0.0006051874,0.0001687087,0.001372442,0.001239655,0.000653189,0.01211218,0.002046612],"category_scores_gemma":[0.007757776,0.0002469805,0.0004831068,0.0001498733,0.002164297,0.001140804,0.0007946414,0.007818826,0.001984376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001424411,"about_ca_system_score_gemma":0.0005514333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005705892,"about_ca_topic_score_gemma":0.000740451,"domain_scores_codex":[0.9990156,0.0002425466,0.000139488,0.0001798113,0.0002644827,0.0001581242],"domain_scores_gemma":[0.9974126,0.001537417,0.0002952601,0.0001537714,0.000333049,0.0002678877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001703328,0.0001909819,0.007492543,0.0005882919,0.000107834,0.03198273,0.0005932996,0.0009880969,0.03849865,0.03621848,0.8151133,0.06652248],"study_design_scores_gemma":[0.0009699775,0.0007598582,0.01200344,0.0002585489,0.0001123537,0.02473414,0.0007904576,0.006223882,0.02877202,0.1014374,0.8237355,0.0002024584],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02422254,0.007521608,0.0009816505,0.9291034,0.02959086,0.00002302439,0.0001168614,0.0001058876,0.00833424],"genre_scores_gemma":[0.3882169,0.0110828,0.001162965,0.490003,0.09253814,0.0000800318,0.0001155526,0.00007292053,0.01672776],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01211218,"threshold_uncertainty_score":0.01033491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03066946943295058,"score_gpt":0.3046061692045168,"score_spread":0.2739366997715662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}