{"id":"W2341924879","doi":"10.1038/srep24090","title":"Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Protein kinase B; Biology; PI3K/AKT/mTOR pathway; Phosphorylation; Protease; Virology; Signal transduction; Immunology; Medicine; Cell biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111365,0.0002493711,0.0003203841,0.0001135978,0.0001176801,0.0003227167,0.0002093534,0.0002143222,0.001685361],"category_scores_gemma":[0.0001305849,0.00009453939,0.0002036533,0.000147027,0.0001343251,0.0001834729,0.00009519026,0.000743048,0.0004215869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002069094,"about_ca_system_score_gemma":0.0002213102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005451441,"about_ca_topic_score_gemma":0.0006728727,"domain_scores_codex":[0.9998751,0.00001620563,0.00001506158,0.00002302556,0.00002960858,0.00004115502],"domain_scores_gemma":[0.9999198,0.00002729507,0.00001131635,0.00001308748,0.000007245991,0.00002125578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003616371,0.0002473345,0.0002348942,0.00004615881,0.000006962593,0.00005668817,0.00001751884,0.00009943961,0.9955787,0.000117659,0.0001242567,0.003108707],"study_design_scores_gemma":[0.00006504107,0.001266008,0.003605961,0.000009507325,0.00001791906,0.0003501358,0.00001750637,0.001219891,0.9908695,0.00005332976,0.002520867,0.000004269549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940553,0.002515768,0.001069868,0.00007858607,0.0000491652,0.00003591484,0.0005764571,0.00006779889,0.001551148],"genre_scores_gemma":[0.9928902,0.001162624,0.001582117,0.00006533976,0.0000130365,0.00006744602,0.001314242,0.0000154053,0.002889571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685361,"threshold_uncertainty_score":0.005638063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081629573016415,"score_gpt":0.2221789790966951,"score_spread":0.211362683366531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}