{"id":"W2342089507","doi":"10.1158/1538-7445.am2015-1369","title":"Abstract 1369: Inhibition of Notch- and EGFR signaling reduces cell viability and angiogenesis in glioblastoma multiforme","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"","keywords":"Notch signaling pathway; Angiogenesis; Cancer research; Cyclin-dependent kinase 8; Hes3 signaling axis; Signal transduction; EGFR inhibitors; Glioma; Medicine; Biology; Epidermal growth factor receptor; Cancer; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692069,0.0004647412,0.0005512536,0.000252905,0.0001096314,0.000191832,0.0002409262,0.0002950339,0.001884826],"category_scores_gemma":[0.000107634,0.0001178831,0.0002813506,0.000208112,0.0001557569,0.0001354488,0.000212407,0.0006120641,0.0003792591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248831,"about_ca_system_score_gemma":0.0003096342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171158,"about_ca_topic_score_gemma":0.001422786,"domain_scores_codex":[0.9998044,0.00003824009,0.00002242392,0.00002253226,0.00006628721,0.00004617282],"domain_scores_gemma":[0.9999328,0.00001354938,0.00001143903,0.000006142387,0.000009901391,0.00002618315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007826203,0.0003079111,0.0002355985,0.00009350026,0.00002082839,0.00005580297,0.00001547935,0.0001020788,0.995218,0.00006440222,0.0001898306,0.002913844],"study_design_scores_gemma":[0.0001541598,0.00463656,0.006095622,0.00001007575,0.00004548845,0.0002376894,0.00002618762,0.001192016,0.9851864,0.00003502126,0.002374311,0.000006486231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993883,0.002949089,0.0006972479,0.0001091029,0.00008003014,0.00003472161,0.0005572868,0.00006459688,0.001624908],"genre_scores_gemma":[0.9920328,0.001444591,0.001309542,0.00007147359,0.00001901878,0.00006046929,0.001429482,0.0000132805,0.003619447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884826,"threshold_uncertainty_score":0.006305337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08217140774517982,"score_gpt":0.3865409631042658,"score_spread":0.3043695553590859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}