{"id":"W2342089507","doi":"10.1158/1538-7445.am2015-1369","title":"Abstract 1369: Inhibition of Notch- and EGFR signaling reduces cell viability and angiogenesis in glioblastoma multiforme","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"","keywords":"Notch signaling pathway; Angiogenesis; Cancer research; Cyclin-dependent kinase 8; Hes3 signaling axis; Signal transduction; EGFR inhibitors; Glioma; Medicine; Biology; Epidermal growth factor receptor; Cancer; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001113384,0.00008447035,0.0002133991,0.0002217703,0.00003907092,0.00001644081,0.00003560932,0.00007686343,0.0001067617],"category_scores_gemma":[0.0000561952,0.00007397633,0.00002803389,0.00030399,0.000160517,0.00009081115,0.0000438466,0.0001769422,0.000001780323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001955756,"about_ca_system_score_gemma":0.0002675035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002091643,"about_ca_topic_score_gemma":0.0004517119,"domain_scores_codex":[0.9988746,0.00004843419,0.000201234,0.0002542506,0.0003752095,0.0002462921],"domain_scores_gemma":[0.999292,0.00008467396,0.00004110047,0.000136991,0.0002590875,0.0001861073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00107905,0.000100284,0.003202797,0.0002626925,0.00001050336,0.00001452814,0.001363934,0.00001512496,0.9734938,0.00002188042,0.00008441302,0.02035099],"study_design_scores_gemma":[0.002059514,0.0004718663,0.01398557,0.0001896237,0.000007296435,0.000003930057,0.001178005,0.00008706617,0.9810025,0.000583642,0.0003547647,0.00007618329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958743,0.003038025,0.000008725994,0.0003933357,0.00004165026,0.0003953159,0.00001904801,0.000009716899,0.0002198822],"genre_scores_gemma":[0.9991044,0.0004544747,0.0001874675,0.00002282881,0.00009641412,0.00005781425,0.000002062539,0.00001465167,0.00005981969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02027481,"threshold_uncertainty_score":0.3161952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08217140774517982,"score_gpt":0.3865409631042658,"score_spread":0.3043695553590859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}