{"id":"W2342101480","doi":"10.1136/annrheumdis-2015-eular.3346","title":"FRI0159 Results of a Single Dose Ascending First-in-Man Trial of a Novel Biologic, Human Stress Protein Rasolvir (BIP) in Rheumatoid Arthritis (RA): The Ragulo Trial","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Medicine; Rheumatoid arthritis; Placebo; Adverse effect; Internal medicine; Arthritis; Surgery; Gastroenterology; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001524951,0.001319136,0.002060313,0.0003171841,0.0005063192,0.001603217,0.00070356,0.001631254,0.004530158],"category_scores_gemma":[0.001877512,0.0003448001,0.002162545,0.0002254015,0.0008753188,0.001001306,0.000351541,0.003588713,0.001228142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008997606,"about_ca_system_score_gemma":0.0007969979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009872284,"about_ca_topic_score_gemma":0.001984661,"domain_scores_codex":[0.9992563,0.0003275376,0.00003200986,0.0001241781,0.00005710507,0.0002028553],"domain_scores_gemma":[0.998847,0.0002699092,0.0001467041,0.0001084873,0.00006058231,0.000567216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.910727,0.008321198,0.0023118,0.0003892858,0.002505088,0.00018489,0.0001177487,0.001367081,0.009254575,0.0005778604,0.002953351,0.06129019],"study_design_scores_gemma":[0.6866146,0.2816702,0.01798934,0.0001027351,0.002120337,0.0003209459,0.0001390058,0.00111344,0.00268825,0.001168628,0.005996416,0.00007612504],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821433,0.007211745,0.0007440496,0.001660316,0.000619911,0.0005084229,0.001427465,0.0001527468,0.005531952],"genre_scores_gemma":[0.9895523,0.001560654,0.0005240649,0.001439655,0.0002604004,0.0002548138,0.001646617,0.00003199281,0.00472969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004530158,"threshold_uncertainty_score":0.0151549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09061393387671213,"score_gpt":0.3441725201651541,"score_spread":0.253558586288442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}