{"id":"W2342126458","doi":"10.1021/acs.orglett.6b00801","title":"Metal-Free Markovnikov-Type Alkyne Hydration under Mild Conditions","year":2016,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic Alkyne Reactions","field":"Chemistry","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Markovnikov's rule; Chemistry; Alkyne; Metal; Combinatorial chemistry; Organic chemistry; Catalysis; Regioselectivity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041638,0.000498124,0.0002966087,0.0001206065,0.0002443132,0.0001977442,0.0004308839,0.0002641746,0.001524043],"category_scores_gemma":[0.0001980448,0.0002118569,0.0002167233,0.0001415646,0.0002075535,0.0004454775,0.0005962324,0.0006045949,0.0007037759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622206,"about_ca_system_score_gemma":0.0003752883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005671197,"about_ca_topic_score_gemma":0.001164439,"domain_scores_codex":[0.9998704,0.0000151182,0.00001069645,0.0000354267,0.00002981924,0.00003853023],"domain_scores_gemma":[0.9999449,0.00000976639,0.00001625209,0.000009803585,0.000007658339,0.00001165438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000699003,0.00002022969,0.00008040321,0.000148756,0.00001597111,0.0001429591,0.00006214696,0.0004193088,0.9892454,0.001904873,0.0003338859,0.007556234],"study_design_scores_gemma":[0.00001178902,0.0001263247,0.0002584445,0.000006214263,0.000008633988,0.0002022961,0.00001223281,0.0008481542,0.9922022,0.0002325085,0.006078159,0.00001309921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.851383,0.002481697,0.1262014,0.0002682732,0.0001788263,0.0003678814,0.0007550654,0.001057375,0.0173064],"genre_scores_gemma":[0.9795806,0.001223626,0.01344179,0.0000383943,0.00001683213,0.00009159395,0.0004216087,0.0000887345,0.005096819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001524043,"threshold_uncertainty_score":0.005098403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265609503905777,"score_gpt":0.2276627114051008,"score_spread":0.215006616366043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}