{"id":"W2342165506","doi":"10.1136/archdischild-2015-310148.1","title":"THE ONTOGENY OF P-GLYCOPROTEIN IN THE DEVELOPING HUMAN BLOOD BRAIN BARRIER: IMPLICATION FOR OPIOID TOXICITY IN NEONATES","year":2015,"lang":"en","type":"article","venue":"Archives of Disease in Childhood","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Medicine; Gestational age; Morphine; Opioid; Ontogeny; Human brain; Toxicity; Blood–brain barrier; Internal medicine; Endocrinology; Central nervous system; Receptor; Pregnancy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003051152,0.0001930401,0.0002606761,0.0006110773,0.0002899626,0.0006182666,0.0002025701,0.0003935579,0.001073179],"category_scores_gemma":[0.0006730568,0.0002073723,0.000276942,0.0002702114,0.0003566106,0.0005448267,0.0005253837,0.0006733679,0.0002546697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000318281,"about_ca_system_score_gemma":0.0004302582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001679304,"about_ca_topic_score_gemma":0.001207286,"domain_scores_codex":[0.9998668,0.00002037314,0.00001106417,0.00003759239,0.00004060154,0.00002346809],"domain_scores_gemma":[0.999698,0.00004447197,0.0001199562,0.00001768389,0.00005912945,0.00006068842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001217046,0.00008782693,0.07067917,0.000237621,0.00003736107,0.003458357,0.0009772155,0.0001958923,0.8805944,0.001228744,0.0004250936,0.04086108],"study_design_scores_gemma":[0.000009313354,0.0004277842,0.9012557,0.0000916236,0.00004655066,0.004727025,0.0008715389,0.0004639605,0.08674956,0.0006937328,0.004638008,0.00002517766],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897525,0.00619386,0.001864158,0.000161754,0.00002321262,0.00002062198,0.0004122934,0.00003039563,0.001541114],"genre_scores_gemma":[0.9876763,0.00723086,0.001913944,0.00007639232,0.00001611378,0.00008096371,0.0003736104,0.0000239192,0.002607904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679304,"threshold_uncertainty_score":0.003590167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340303689014404,"score_gpt":0.2772734971679303,"score_spread":0.2638704602777862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}