{"id":"W2342194767","doi":"10.1016/j.freeradbiomed.2016.04.014","title":"The thioredoxin and glutathione-dependent H2O2 consumption pathways in muscle mitochondria: Involvement in H2O2 metabolism and consequence to H2O2 efflux assays","year":2016,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Thioredoxin reductase; Biochemistry; Glutathione; Mitochondrion; Chemistry; Efflux; Thioredoxin; Antioxidant; Hydrogen peroxide; Glutathione reductase; Glutathione peroxidase; Peroxidase; Respiratory chain; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006044002,0.0005708435,0.0002335931,0.0003529891,0.0005072603,0.0003177568,0.0004448073,0.0005342275,0.001865182],"category_scores_gemma":[0.0002909612,0.0003117426,0.0004017088,0.000586948,0.0004988508,0.0007307508,0.0004363115,0.0007508654,0.0002900837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446015,"about_ca_system_score_gemma":0.0003424043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455109,"about_ca_topic_score_gemma":0.002082768,"domain_scores_codex":[0.9996567,0.00009175402,0.00003762505,0.00005624124,0.00007712762,0.00008054572],"domain_scores_gemma":[0.9997512,0.00004254999,0.00003572474,0.00003538911,0.00005886084,0.00007633796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077761,0.00006896898,0.0009309335,0.00007435942,0.00002629928,0.00004719091,0.0001249808,0.00006757672,0.9958775,0.0003064372,0.00003307133,0.001364833],"study_design_scores_gemma":[0.00003686137,0.0004756433,0.008553827,0.000005989393,0.00007290579,0.0001480994,0.0001008831,0.001298705,0.9882658,0.0001690077,0.000864344,0.000007998179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799948,0.002456217,0.01436549,0.000139494,0.00005405916,0.0001096804,0.0005055689,0.0000746489,0.002299925],"genre_scores_gemma":[0.9799737,0.001143011,0.01029692,0.00007108785,0.00002560239,0.000157746,0.001337641,0.00003207917,0.006962197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865182,"threshold_uncertainty_score":0.006239653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01841939647740479,"score_gpt":0.2690250511843907,"score_spread":0.2506056547069859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}