{"id":"W2342292924","doi":"10.1080/15384101.2016.1158362","title":"Structure of the human dimeric ATM kinase","year":2016,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children","keywords":"Autophosphorylation; Biology; Kinase; Ataxia-telangiectasia; Cell biology; Protein kinase domain; DNA-PKcs; Signal transduction; Phosphorylation; Biochemistry; DNA; Protein kinase A; DNA damage; Biophysics; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081452,0.0003852125,0.0002662945,0.0001820968,0.0004309449,0.0004809576,0.0005090027,0.0004137872,0.002209764],"category_scores_gemma":[0.0001663491,0.0002302914,0.0001858352,0.0002114938,0.000155581,0.0003004587,0.0001865215,0.0005958601,0.00119663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005981563,"about_ca_system_score_gemma":0.0003426763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007896296,"about_ca_topic_score_gemma":0.000478538,"domain_scores_codex":[0.9999427,0.000008078324,0.00000349847,0.0000213664,0.00001682749,0.000007685869],"domain_scores_gemma":[0.9999433,0.000006770506,0.00001337003,0.000005987078,0.00001219375,0.00001846716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001223147,0.0003886713,0.00247196,0.0004676759,0.00007235782,0.001332966,0.0003763709,0.01183192,0.9210218,0.01093725,0.01016306,0.03971295],"study_design_scores_gemma":[0.0004174007,0.001985137,0.02631564,0.0001579739,0.000195461,0.00505437,0.0005482445,0.1004463,0.5413432,0.01242405,0.3108957,0.000216479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398783,0.01443232,0.01967572,0.001704224,0.0003381956,0.0001091237,0.002198616,0.0005198015,0.02114384],"genre_scores_gemma":[0.9727051,0.003625379,0.008013195,0.000296062,0.0000610293,0.00004183815,0.006107005,0.00004460662,0.00910574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002209764,"threshold_uncertainty_score":0.007392347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003972604586473417,"score_gpt":0.2069288041786804,"score_spread":0.202956199592207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}