{"id":"W2342292924","doi":"10.1080/15384101.2016.1158362","title":"Structure of the human dimeric ATM kinase","year":2016,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children","keywords":"Autophosphorylation; Biology; Kinase; Ataxia-telangiectasia; Cell biology; Protein kinase domain; DNA-PKcs; Signal transduction; Phosphorylation; Biochemistry; DNA; Protein kinase A; DNA damage; Biophysics; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002499969,0.0000664282,0.00005670168,0.000006634972,0.00003870856,0.000002690703,0.000191515,0.00006598199,0.00009417579],"category_scores_gemma":[0.0000126979,0.00003642358,0.00006349784,0.00003323194,0.00005507516,0.00000103816,0.0001129027,0.00002489235,0.000007411593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005047797,"about_ca_system_score_gemma":0.00001500021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007297841,"about_ca_topic_score_gemma":0.00000776036,"domain_scores_codex":[0.9995772,0.00002663702,0.0000785213,0.000144889,0.00006589894,0.0001068301],"domain_scores_gemma":[0.9994909,0.000003267148,0.00005290173,0.0004046908,0.00002078137,0.00002751863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003369169,0.00001471786,0.0009510341,0.000005946028,0.000005418152,3.324937e-7,0.00001016436,0.000002609813,0.9975616,0.0001016226,0.0006191236,0.000724019],"study_design_scores_gemma":[0.0002170204,0.00005382415,0.002670189,0.000005788819,0.000006771672,0.000001343354,0.000008432096,0.000001284112,0.9915705,0.0006750103,0.004728924,0.00006095662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978116,0.000111845,0.0001080187,0.00004308298,0.0001487873,0.0000695147,0.0000116051,0.000006420037,0.001689148],"genre_scores_gemma":[0.9968797,0.000006034389,0.0001490357,0.00006968222,0.00006241896,0.000001619468,0.000004092533,0.0000123099,0.002815138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005991186,"threshold_uncertainty_score":0.148531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003972604586473417,"score_gpt":0.2069288041786804,"score_spread":0.202956199592207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}