{"id":"W2342353522","doi":"10.1021/acs.biochem.5b00822","title":"Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Center for Research Resources; Natural Sciences and Engineering Research Council of Canada","keywords":"Allosteric regulation; Phosphoenolpyruvate carboxykinase; Gluconeogenesis; Chemistry; Non-competitive inhibition; Binding site; Biochemistry; Enzyme; Allosteric enzyme; Stereochemistry; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146554,0.0002289097,0.0001728317,0.00009688702,0.0001099871,0.0002818688,0.0003019914,0.0001990717,0.0006309577],"category_scores_gemma":[0.0001542061,0.000133928,0.000206281,0.00009576741,0.0002919445,0.0001345094,0.0002063595,0.0003973854,0.0002049127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002726642,"about_ca_system_score_gemma":0.000137338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008333367,"about_ca_topic_score_gemma":0.001066384,"domain_scores_codex":[0.9998817,0.00002501829,0.000009340612,0.00002345727,0.00003299722,0.00002748421],"domain_scores_gemma":[0.9999359,0.00001732809,0.0000214326,0.000007325218,0.000005362941,0.0000126949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001105063,0.00002783937,0.0001332772,0.00003576345,0.000003715965,0.00004092658,0.00001352737,0.0001332407,0.99815,0.000169727,0.00002623849,0.001155332],"study_design_scores_gemma":[0.00001959063,0.0001145168,0.002702419,0.000004164598,0.000006151914,0.0001395034,0.00001772379,0.002757503,0.9929966,0.00008931808,0.001146863,0.000005601109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905244,0.003696997,0.002998443,0.0001919848,0.00003171559,0.00001976562,0.00006875295,0.0001207543,0.002347183],"genre_scores_gemma":[0.9972343,0.0008267188,0.001339209,0.00003871439,0.000006462801,0.00001018533,0.0000488495,0.000008380412,0.0004872982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008333367,"threshold_uncertainty_score":0.00211072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326745593944966,"score_gpt":0.2481022427711526,"score_spread":0.2348347868317029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}