{"id":"W2342436442","doi":"10.4049/jimmunol.1402890","title":"Structures of Preferred Human IgV Genes–Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Gene; Germline; Rhamnose; Serotype; Peptide; Streptococcus pneumoniae; Antigen; Genetics; Antibody; Molecular biology; Microbiology; Biochemistry; Polysaccharide; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009900812,0.0002260363,0.000652348,0.0002993207,0.000306494,0.00001420694,0.0005064544,0.0002435011,0.0001091546],"category_scores_gemma":[0.0004109897,0.0001334127,0.0001466157,0.0001497376,0.0008907224,0.0001648788,0.0001447243,0.0003115374,0.00000490008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003821412,"about_ca_system_score_gemma":0.0001159684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395146,"about_ca_topic_score_gemma":0.00002354249,"domain_scores_codex":[0.9976209,0.001114713,0.0006928866,0.0001763418,0.00008908787,0.0003061083],"domain_scores_gemma":[0.9973359,0.0005170059,0.001281497,0.0003632282,0.0004928871,0.00000945418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002065827,0.0001250971,0.003706604,0.0000268784,0.0006580144,0.000002137202,0.00233845,0.00002518384,0.9869637,0.0004656479,0.00005413851,0.003568283],"study_design_scores_gemma":[0.002138465,0.0009962106,0.4149481,0.0001296806,0.000124629,0.0000587739,0.002207373,8.543198e-7,0.5784778,0.0005771229,0.000218982,0.0001219729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819943,0.01161618,0.004939671,0.0005995757,0.0003818942,0.000387563,0.0000346943,0.00001380024,0.00003233458],"genre_scores_gemma":[0.9993898,0.000314239,0.00005085403,0.00003115057,0.000007071693,0.000002735058,0.000004500093,0.00001475127,0.0001848792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4112415,"threshold_uncertainty_score":0.544041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422754916268347,"score_gpt":0.2575265468483506,"score_spread":0.2332989976856672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}