{"id":"W2342541592","doi":"10.1016/j.cjca.2015.07.582","title":"LYSOPHOSPHATIDIC ACID ACTIVATES BMP2 GENE PROMOTER THROUGH A RHOA-PHOSPHORYLATED P65 SERINE 536 PATHWAY IN AORTIC VALVE INTERSTITIAL CELLS: IMPLICATION FOR CALCIFIC AORTIC VALVE DISEASE","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Lysophosphatidic acid; RHOA; Phosphorylation; Signal transduction; RUNX2; Medicine; Cancer research; Cell biology; Bone morphogenetic protein 2; Transcription factor; Internal medicine; Biology; Biochemistry; Receptor; Gene; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544514,0.0003295615,0.0002013752,0.0003349223,0.0002908752,0.0003783201,0.000171242,0.0002571072,0.0019032],"category_scores_gemma":[0.0001135145,0.0002230379,0.0003362481,0.0001494623,0.0002723254,0.0001973809,0.0003062641,0.0006513632,0.0004799734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003367226,"about_ca_system_score_gemma":0.0004708417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001973947,"about_ca_topic_score_gemma":0.002999235,"domain_scores_codex":[0.9998261,0.0000220997,0.0000106398,0.00002253627,0.00005154522,0.00006715453],"domain_scores_gemma":[0.9999268,0.000006860826,0.00001464531,0.000007595438,0.00001287371,0.00003118733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002434285,0.00002476966,0.0003734156,0.00002461234,0.000003579492,0.0001488597,0.000024671,0.00001885428,0.9982633,0.0001665108,0.00004655851,0.0006614898],"study_design_scores_gemma":[0.0001045118,0.0002222705,0.03379838,0.00001613135,0.00004334398,0.0005251997,0.0003406168,0.00113624,0.9607044,0.0002764812,0.00282208,0.00001027723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925873,0.001517824,0.002473947,0.0002937012,0.00006454306,0.00002788651,0.000366832,0.00005671676,0.002611323],"genre_scores_gemma":[0.9939855,0.0006974983,0.0009071514,0.00006632852,0.00001500582,0.00002777408,0.0003261758,0.000010948,0.003963585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001973947,"threshold_uncertainty_score":0.006366849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911323805397862,"score_gpt":0.2545385626932758,"score_spread":0.2354253246392972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}