{"id":"W2342613178","doi":"10.1128/jvi.02779-15","title":"A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Biology; Antibody; Epitope; Glycoprotein; Cytotoxicity; Virology; Cell biology; Molecular biology; Immunology; Genetics; In vitro; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001711392,0.0002369949,0.0007580774,0.0002141092,0.0001498815,0.00001404752,0.0004809918,0.0003667902,0.0001188042],"category_scores_gemma":[0.0008515589,0.0001408282,0.0002814532,0.0001413664,0.0006608966,0.00009708303,0.0001676869,0.0004528527,0.00007436452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007600785,"about_ca_system_score_gemma":0.0005504492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009674759,"about_ca_topic_score_gemma":0.00005358197,"domain_scores_codex":[0.9969653,0.001134971,0.000976941,0.0002379533,0.000164639,0.0005202031],"domain_scores_gemma":[0.9974433,0.0007311917,0.0008905599,0.0003596978,0.0004747218,0.0001005375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005111121,0.0004531747,0.07906993,0.00002170766,0.000741117,0.0001010842,0.0006027744,0.000002440427,0.8547754,0.00004241183,0.05906658,0.00001227551],"study_design_scores_gemma":[0.01318466,0.003357238,0.02537313,0.00005906478,0.0002009442,0.0007323832,0.0004272145,0.000007338637,0.9156181,0.0006869546,0.04013653,0.0002164067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840034,0.005796254,0.0002935207,0.007689828,0.0004257888,0.0004571149,0.001273544,0.000009932458,0.0000506806],"genre_scores_gemma":[0.9976886,0.0003362492,0.0001619664,0.0005650552,0.00004693801,0.00001170393,0.0001106163,0.00002117767,0.001057678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06084275,"threshold_uncertainty_score":0.5742809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998250481772722,"score_gpt":0.2821699695013155,"score_spread":0.2621874646835883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}