{"id":"W2342613178","doi":"10.1128/jvi.02779-15","title":"A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Biology; Antibody; Epitope; Glycoprotein; Cytotoxicity; Virology; Cell biology; Molecular biology; Immunology; Genetics; In vitro; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027752,0.000125682,0.0001310998,0.00009324991,0.0002182425,0.0001737851,0.0001354704,0.0002061912,0.0008291676],"category_scores_gemma":[0.0001949939,0.00004715997,0.0001484004,0.00005317326,0.0001470969,0.0001255865,0.0001285785,0.0002323722,0.0002085633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001394376,"about_ca_system_score_gemma":0.0001658209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006766703,"about_ca_topic_score_gemma":0.0005390746,"domain_scores_codex":[0.999911,0.00002017652,0.000007133576,0.00001430659,0.00002239239,0.00002504733],"domain_scores_gemma":[0.9998521,0.00003684309,0.0000392678,0.00001256177,0.00002051008,0.00003884087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002282592,0.00002883671,0.00154234,0.00001957557,0.000006165108,0.0001208148,0.00001991904,0.00004644156,0.9966222,0.00007661228,0.00002286362,0.001265971],"study_design_scores_gemma":[0.00005759282,0.0009694096,0.08360566,0.00001512825,0.00004267044,0.003064583,0.00009237759,0.001405986,0.9085232,0.0001701348,0.00204044,0.00001273732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983703,0.0002675819,0.0008558587,0.00002627513,0.0000063644,0.000007887517,0.00003644429,0.00001019192,0.0004192082],"genre_scores_gemma":[0.9993939,0.00006732135,0.0003566369,0.00001318394,0.000003310577,0.000001848521,0.00004593974,0.000002022537,0.0001158183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008291676,"threshold_uncertainty_score":0.002773821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998250481772722,"score_gpt":0.2821699695013155,"score_spread":0.2621874646835883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}