{"id":"W2342653402","doi":"10.1038/ncomms11451","title":"Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Crete; Bodossaki Foundation; Ottawa Hospital Research Institute; Cancer Research Institute","keywords":"Midbody; Abscission; Cytokinesis; Aurora inhibitor; Cell biology; Aurora B kinase; Chromatin; Phosphorylation; Biology; Genetics; Cell division; Cell cycle; DNA; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413975,0.0001055174,0.00007712795,0.00001510575,0.000262259,0.0000253508,0.000570996,0.0002267841,0.000009982847],"category_scores_gemma":[0.0001059696,0.00006153517,0.00004714382,0.00004626565,0.0001244022,0.000004881103,0.0005744532,0.0002244125,0.000004717068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001840669,"about_ca_system_score_gemma":0.00002725823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009331933,"about_ca_topic_score_gemma":0.0001584268,"domain_scores_codex":[0.9993069,0.0001154602,0.0001724184,0.0001902141,0.00008380196,0.0001312489],"domain_scores_gemma":[0.9984212,0.00005311503,0.00009983331,0.001324339,0.00005493003,0.00004657237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005783421,0.00004835932,0.0003046975,0.0000038792,0.00002037596,7.113443e-8,0.00004870413,3.954734e-7,0.9795117,0.0005649747,0.008785482,0.01070561],"study_design_scores_gemma":[0.0006752793,0.00009907185,0.005307442,0.0001051045,0.00004242379,0.00003962811,0.0001385634,0.0001750706,0.5552011,0.0003882081,0.4375222,0.0003059129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527987,0.02188516,0.002019872,0.0194649,0.000125562,0.000576559,0.0001274521,0.00004109303,0.002960721],"genre_scores_gemma":[0.9938555,0.002650954,0.00147606,0.0003764121,0.0000479272,0.00003394536,0.0001124322,0.00001597276,0.001430775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4287367,"threshold_uncertainty_score":0.2509331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00710367326764145,"score_gpt":0.2640959331428745,"score_spread":0.2569922598752331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}