{"id":"W2342699699","doi":"10.1097/ftd.0000000000000192","title":"Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy","year":2015,"lang":"en","type":"review","venue":"Therapeutic Drug Monitoring","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Child and Family Research Institute; University of Toronto; SickKids Foundation; BC Children's Hospital; Centre Hospitalier de l’Université de Montréal; Hospital for Sick Children; University of British Columbia","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Université de Montréal; Child and Family Research Institute; BC Children's Hospital; London Health Sciences Centre","keywords":"Warfarin; VKORC1; Medicine; Dosing; CYP2C9; Pharmacogenetics; Vitamin K epoxide reductase; Genetic testing; Intensive care medicine; Adverse effect; Internal medicine; Genotype; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03699023,0.002014371,0.004748852,0.008517768,0.001725519,0.005107842,0.00533388,0.009048045,0.01010369],"category_scores_gemma":[0.1499688,0.00147483,0.006114204,0.006176545,0.002433362,0.005291303,0.004115902,0.007504043,0.003891478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005643391,"about_ca_system_score_gemma":0.02344796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01299641,"about_ca_topic_score_gemma":0.01936194,"domain_scores_codex":[0.9605111,0.01762435,0.01176632,0.002305568,0.006738224,0.001054381],"domain_scores_gemma":[0.8510983,0.09000973,0.01408027,0.002492286,0.03939649,0.002922973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003752505,0.0002134288,0.002810099,0.1823881,0.002440568,0.0005607025,0.001676795,0.001589571,0.0005793008,0.007757182,0.2608,0.5388091],"study_design_scores_gemma":[0.0005311708,0.0001932679,0.002826482,0.5219597,0.004313052,0.0005493911,0.0009555886,0.0005315607,0.0003228821,0.01340794,0.4542465,0.0001623751],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001243108,0.8136934,0.005314974,0.1571452,0.009709992,0.001035712,0.00177292,0.0002208983,0.009863838],"genre_scores_gemma":[0.01770921,0.8718467,0.041476,0.05837053,0.003789649,0.002282285,0.002081505,0.000096768,0.002347432],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03699023,"threshold_uncertainty_score":0.1956254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5431120409138199,"score_gpt":0.5915064735913468,"score_spread":0.04839443267752686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}