{"id":"W2342710380","doi":"10.1016/j.ijpharm.2016.04.067","title":"Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector through spray drying","year":2016,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; QuantERA; McMaster University","keywords":"Differential scanning calorimetry; Mannitol; Spray drying; Excipient; Trehalose; Thermal stability; Chemistry; Chromatography; Maltodextrin; Dextran; Chemical engineering; Materials science; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003039939,0.0002984568,0.0002495416,0.0001695119,0.0001258284,0.0001880417,0.0002085766,0.0002364661,0.0005785035],"category_scores_gemma":[0.0003663141,0.0001131022,0.0003236583,0.0001585553,0.0001599804,0.0002127315,0.0001430353,0.0002524299,0.0001239395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182235,"about_ca_system_score_gemma":0.0001553688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006027785,"about_ca_topic_score_gemma":0.000876892,"domain_scores_codex":[0.9998403,0.00002377538,0.00001462749,0.00003160161,0.00006026424,0.0000293142],"domain_scores_gemma":[0.9998657,0.00003742301,0.00003789282,0.000009669494,0.00003683379,0.00001250571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008427363,0.00001308504,0.00005566392,0.00004527702,0.000004859547,0.00002394349,0.00001260394,0.0000861704,0.9979941,0.00001651813,0.00001061242,0.001653013],"study_design_scores_gemma":[0.000004546267,0.0002291957,0.0003886636,0.000003104169,0.00001163085,0.00003677547,0.000007673666,0.000307561,0.9987063,0.000002705876,0.0002993295,0.000002505236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927799,0.001871633,0.004708399,0.00002001109,0.00001879922,0.00005191532,0.00006767593,0.00004235573,0.0004393608],"genre_scores_gemma":[0.9912491,0.001446165,0.006102431,0.00002088205,0.00000506467,0.00003476334,0.00009446086,0.00002716714,0.00101997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006027785,"threshold_uncertainty_score":0.001935244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1477207728517914,"score_gpt":0.4603420773349918,"score_spread":0.3126213044832004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}