{"id":"W2342749204","doi":"10.1038/mp.2016.59","title":"Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology","year":2016,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Kuopion Yliopistollinen Sairaala; Sigrid Juséliuksen Säätiö; Fondation pour la Recherche Médicale; Academy of Finland; Itä-Suomen Yliopisto; Agence Nationale de la Recherche; Institute of Genetics; National Institutes of Health; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Centre National de la Recherche Scientifique; Belgian Federal Science Policy Office; Alzheimer's Association","keywords":"Biology; Erythropoietin-producing hepatocellular (Eph) receptor; Genetically modified mouse; Focal adhesion; Alzheimer's disease; Neurotoxicity; Neurodegeneration; Genetics; In vivo; Progressive supranuclear palsy; Transgene; Gene; Toxicity; Neuroscience; Cell biology; Pathology; Kinase; Medicine; Signal transduction; Disease; Atrophy; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031654,0.0001434273,0.0002867281,0.0002080262,0.0000344166,0.000005936497,0.00005621292,0.00008801309,0.0002565107],"category_scores_gemma":[0.00004326545,0.0001054428,0.0001123646,0.0001341752,0.0001999583,0.0001020281,0.00004902364,0.0001069236,0.00001135401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009906949,"about_ca_system_score_gemma":0.0001355207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002303622,"about_ca_topic_score_gemma":0.00002354234,"domain_scores_codex":[0.9986585,0.0001431655,0.0002969852,0.00031639,0.0003447418,0.000240237],"domain_scores_gemma":[0.9992195,0.00002375207,0.0001248825,0.000334486,0.00009867321,0.0001987215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009312056,0.0004999451,0.968932,0.00004160648,0.002896632,0.0001547092,0.00005559168,0.000002359309,0.02345712,0.0004104043,0.0002479097,0.00237051],"study_design_scores_gemma":[0.003572892,0.0005520767,0.9755628,0.0001300115,0.0004719358,0.00005318995,0.0000955892,0.00001975994,0.01644897,0.002969373,0.00001241073,0.0001110572],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880221,0.01041642,0.0006387274,0.0002954731,0.00008649404,0.0002670742,0.00005550747,0.00001335495,0.0002048027],"genre_scores_gemma":[0.9982591,0.000102091,0.001463149,0.00005331392,0.0000366873,0.00001953335,0.00001091533,0.00002536135,0.00002985014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01031433,"threshold_uncertainty_score":0.4299831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502629227938023,"score_gpt":0.285310395399827,"score_spread":0.2702841031204468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}